|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the successful spatiotemporal imaging of NE in ALI model mice also made it a promising new tool in clinical diagnosis for ALI and other lung diseases.
|
30626182 |
2019 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
However, progression to large-scale or multicenter clinical trials has been hampered by the fact that the current gold standard methodology of evaluating airway NE inhibition, bronchoalveolar lavage (BAL), is invasive, difficult to standardize across sites and excludes those with severe lung disease.
|
29960875 |
2019 |
|
Lung diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lung disease in alpha-1-antitrypsin deficiency (AATD) results from dysregulated proteolytic activity, mainly by neutrophil elastase (HNE), in the lung parenchyma.
|
30633749 |
2019 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that surface-bound NE activity may play an important role in the pathogenesis and serve as novel biomarker in CF lung disease.
|
29545279 |
2018 |
|
Lung diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lung disease in patients with CF is associated with neutrophil-dominated inflammation and elevated levels of the serine protease, neutrophil elastase (NE).
|
29401615 |
2018 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results support a feed-forward cycle of NE-generated ceramide and ceramide-driven cytokine signaling that may be a potential target for intervention in lung disease typified by chronic neutrophilic inflammation.
|
29025713 |
2018 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>Pseudomonas</i> on BAL was associated with positive neutrophil elastase (OR 4.17, 95% CI 2.04-8.53; p<0.001), increased interleukin-8 (p<0.001), increased all baseline PRAGMA computed tomography scores (p<0.001), progression of PRAGMA computed tomography scores (p<0.05) and increased risk of respiratory exacerbations (incidence rate ratio 2.11, 95% CI 1.15-3.87; p=0.017).In children with CF OPSs only marginally change the probability of detecting lower airway <i>Pseudomonas</i> and are not associated with lung disease indices nor exacerbations risk.
|
29678944 |
2018 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Areas covered: Measurement of NE activity has emerged as a promising biomarker strategy in inflammatory lung disease.
|
28854829 |
2017 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The Role of Neutrophil Elastase Inhibitors in Lung Diseases.
|
28442313 |
2017 |
|
Lung diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The low AAT concentration can result in uninhibited neutrophil elastase activity in the lung, leading to pulmonary tissue damage and lung disease.
|
28752443 |
2017 |
|
Lung diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
C5a levels also correlated positively with concentrations of other sputum markers associated with worse CF lung disease including neutrophil elastase (P < 0.001), myeloperoxidase activity (P = 0.006) and DNA concentration (P < 0.001).
|
28278205 |
2017 |
|
Lung diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Various mutations in AAT cause alpha-1 antitrypsin deficiency (AATD), a rare hereditary disorder that results in liver disease due to accumulation of AAT aggregates and lung disease from excessive neutrophil elastase activity.
|
28752452 |
2017 |
|
Lung diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We used the Scnn1b-Tg mouse as a model of CF lung disease and determined effects of genetic deletion of NE (NE(-/-)) on the pulmonary phenotype.
|
24678594 |
2014 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
The findings support a pre-eminent role for neutrophil elastase as the critical protease responsible for SP-D depletion in inflammatory lung disease.
|
18211966 |
2008 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, deficiency in a weak intracellular inhibitor of NE results in an acute inflammatory response that protects from P. aeruginosa but does not cause lung disease.
|
17878334 |
2007 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Human neutrophil elastase (NE) plays a critical role in lung disease, but the paucity of neutrophils in the atheromatous plaque has led to neglect of its potential role in vascular biology.
|
12771009 |
2003 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Excess neutrophil elastase is an important determinant of pulmonary disease in CF. alpha1-antitrypsin (AAT), also known as alpha1-proteinase inhibitor (alpha1PI) is a major modulator of elastase activity.
|
11313771 |
2001 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that UTI is applicable to patients with a variety inflammatory lung diseases in which NE plays a pivotal role.
|
9030096 |
1997 |