ELANE, elastase, neutrophil expressed, 1991

N. diseases: 346; N. variants: 33
Disease: Pulmonary Fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.220 Biomarker disease BEFREE Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis. 25743626 2015
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.220 Biomarker disease RGD The authors hypothesized that synthetic neutrophil elastase inhibitor, sivelestat (ONO-5046), can inhibit the bleomycin-induced pulmonary fibrosis in rats by blocking the apoptotic pathways in epithelial cells. 19995276 2009
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.220 Biomarker disease BEFREE Thus, NE could be considered to have potential multiple roles in the pathogenesis of both emphysema and lung fibrosis. 18243764 2008