SERPINB1, serpin family B member 1, 1992

N. diseases: 41; N. variants: 2
Disease: Endotoxemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.010 AlteredExpression phenotype BEFREE Consequently, knockdown or deletion of SERPINB1 prompted spontaneous activation of caspase-1/-4/-5/-11, release of the cytokine IL-1β and pyroptosis, inducing elevated inflammation after non-hygienic co-housing with pet-store mice and enhanced sensitivity to lipopolysaccharide- or Acinetobacter baumannii-induced endotoxemia. 30692621 2019