A2M, alpha-2-macroglobulin, 2

N. diseases: 147; N. variants: 3
Disease: Amyloidosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.020 GeneticVariation disease LHGDN Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. 18382889 2008
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.020 AlteredExpression disease BEFREE We found that this endocytic receptor conferred protection against amyloid beta-protein toxicity in the presence of activated alpha(2)-macroglobulin and its down-regulation via inhibition by receptor-associated protein or transfection of cells with presenilin 1, increased susceptibility to amyloid beta-protein toxicity. 10899157 2000