Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE CRTC2 is unphosphorylated and therefore constitutively activated in LKB1-mutant NSCLC, where it promotes tumor growth, in part via the induction of the inhibitor of DNA binding 1 (ID1), a bona fide CREB target gene. 31355336 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE The use of a PI3K/TORC1/TORC2 inhibitor, tested <i>in vitro</i> and <i>in vivo</i>, inhibited pRPS6 and NRF2 expression and caused cell and tumor growth reduction, in anti-HER2-resistant models. 30504425 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Uncoupling TORC2 from AGC kinases inhibits tumour growth. 29156676 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene that preserves genome integrity by stimulating transcription of MMR genes. 26004186 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE A unique attribute of these tumors is the deregulation of TORC2. 26438156 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE Whether proliferation of tumor cells depends on TORC2 activity has not been thoroughly explored. 18831768 2008