Since NE signaling contributes to diverse brain functions, we hypothesize that promoter variation within the human NET gene (solute carrier family 6, member 2; SLC6A2) may impact risk for NE-related disorders, including depression, attention deficit hyperactive disorder (ADHD), and autonomic dysfunction.
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528CNET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
<b>Methods:</b> We compared ERP waveforms during the processing of emotional faces in a population sample of 58 6-11-year-olds who completed self-reported measures of trait and state anxiety and depression.
The CFS over other methods leads to a good overall performance in most cases, especially when KNN classifier is used for P300 component classification, illustrating that ERP component may be applied as a tool for auxiliary diagnosis of depression.
The reduced task-related ERP response in individuals with depression suggests significant impairments in these individuals in stimulus integration and response functions.
In support, recent ERP studies find that, following reward feedback, a larger reward positivity (RewP) is associated with greater vulnerability for bipolar spectrum disorders, whereas a smaller RewP is associated with greater vulnerability for depression.