Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aortic walls of patients with abdominal aortic aneurysms (AAA) and of healthy controls were examined for elastin, collagen I and III, and the intermediate filament proteins desmin and vimentin by immunohistochemical, enzyme histochemical, and routine histological techniques.
|
3539908 |
1986 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, polymorphisms of ELN, estrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor (PR) and TGFbeta1 genes and their products may be involved in the abdominal aortic aneurysm (AAA) development.
|
15698546 |
2004 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
As matrix degradation contributes to the progression of AAA, the destruction and degradation of elastin fibers caused by an increase in matrix metalloproteinases (MMPs) plays a pivotal role in the development of AAA.
|
15800662 |
2005 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The substantial production of elastin and elastic fibre-like structures that we observed in the AAA neointima, which was not observed elsewhere within AAA tissues, provides a unique opportunity to capitalize on this autoregenerative phenomenon and direct it from the standpoint of matrix organization towards restoring healthy aortic matrix structure, mechanics and function.
|
24799390 |
2017 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that miR-516a-5p may regulate MTHFR, MMP-2, and TIMP-1 expressions in human VSMCs, possibly promoting the disruption of Hcy metabolism and proteolytic degradation of elastin for AAA formation.
|
28288890 |
2017 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Histological alterations, including aortic wall thickening, collagen deposition, elastin fragmentation, and vascular smooth muscle cell apoptosis in AAA tissue of ApoE KO mice, were also significantly attenuated in LMP7/ApoE dKO mice.
|
30642978 |
2019 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The systematic search was performed in two stages: firstly, using the terms AAA and gender/sex/women; and secondly, adding the terms "elastin", "collagen" and "vascular smooth muscle cells", in order to filter the search for studies relevant to our focus on the aneurysm wall.
|
29452784 |
2018 |
Aortic Aneurysm, Abdominal
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It was shown that CYP2J2 overexpression attenuated matrix metalloproteinase expression and activity, elastin degradation, and AAA formation, which was associated with reduced aortic inflammation and macrophage infiltration.
|
23446230 |
2013 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abdominal aortic aneurysms (AAAs) involve slow proteolysis and loss of structural matrix components (collagen and elastin), which lead to wall thinning, weakening and ultimate rupture.
|
25376929 |
2017 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice.
|
19720934 |
2009 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, we show that this novel targeting technique can be used as a diagnostic tool to predict the degree of elastin damage and therefore rupture potential in AAAs better than the extent of dilation.
|
31281538 |
2019 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The growth of the AAA is dependent on proteolytic degradation of elastin.
|
17721627 |
2007 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, knockdown of <i>PVT1</i> reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines.
|
30726659 |
2019 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The decreased elastin concentration relative to collagen in AAAs may be explained, in part, by the changes in message level of elastin and collagen.
|
1641765 |
1992 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Remnant Epitope Autoimmunity in Human Abdominal Aortic Aneurysm: A Pilot Study with Elastin Peptides.
|
28602894 |
2017 |
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abdominal aortic aneurysms (AAA) are characterized by structural alterations of the aortic wall resulting from the degradation of elastic fibres and an increase of collagen/elastin ratio.
|
20725971 |
2010 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that polymorphisms in MMP2, MMP3, MMP-13, and ELN genes may independently contribute to the pathogenesis of AAA.
|
22094117 |
2012 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
A2AR activation attenuates AAA formation partly by inhibiting immune cell recruitment and reducing elastin fragmentation.
|
23413358 |
2013 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Degradation of extracellular matrix, especially elastin, within the aortic wall is a hallmark of abdominal aortic aneurysms (AAAs).
|
9588507 |
1998 |
Aortic Aneurysm, Abdominal
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression levels of tropoelastin and lysyl oxidase were significantly higher in the EGCG group immediately before AAA induction, indicating promoted elastoregeneration by EGCG administration (tropoelastin: 0.59 ± 0.36 control vs 1.24 ± 0.36 EGCG [P < .05], lysyl oxidase: 0.77 ± 0.45 control vs 1.34 ± 0.4 EGCG [P < .05]) (fold increase).
|
27473778 |
2017 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
Aortic Aneurysm, Abdominal
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that miR-181b was overexpressed in symptomatic human atherosclerotic plaques and abdominal aortic aneurysms and correlated with decreased expression of predicted miR-181b targets, tissue inhibitor of metalloproteinase-3, and elastin.
|
27756793 |
2017 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Imatinib administration (50 mg/kg/d, i.g.) was carried out one week after the establishment of elastase-induced AAA in rats, stabilizing aneurysm progression and improving survival rate via decreasing the aortic diameter and preventing elastin degradation.
|
31325435 |
2019 |
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that destruction of the elastin fiber network during AAA formation is dependent on macrophage-derived MT1-MMP, which unexpectedly serves as a direct-acting regulator of macrophage proteolytic activity.
|
19010778 |
2009 |
Aortic Aneurysm, Abdominal
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Human AAA and control aorta corroborated these elastin and 5-LO expression patterns.
|
25324573 |
2014 |