|
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aortic walls of patients with abdominal aortic aneurysms (AAA) and of healthy controls were examined for elastin, collagen I and III, and the intermediate filament proteins desmin and vimentin by immunohistochemical, enzyme histochemical, and routine histological techniques.
|
3539908 |
1986 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, polymorphisms of ELN, estrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor (PR) and TGFbeta1 genes and their products may be involved in the abdominal aortic aneurysm (AAA) development.
|
15698546 |
2004 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, knockdown of <i>PVT1</i> reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines.
|
30726659 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Remnant Epitope Autoimmunity in Human Abdominal Aortic Aneurysm: A Pilot Study with Elastin Peptides.
|
28602894 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abdominal aortic aneurysms (AAA) are characterized by structural alterations of the aortic wall resulting from the degradation of elastic fibres and an increase of collagen/elastin ratio.
|
20725971 |
2010 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results from SIRT1<sup>flox/flox</sup> mice and macrophage specific SIRT1 knockout mice with treatment of angiotensin II (Ang II) for 4 weeks showed that macrophage specific deficiency of SIRT1 increased the incidence of AAA and exacerbated the severity, including more severe aneurysm types, enlarged diameter of the aneurysm and increased degradation of elastin.
|
29396144 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
As matrix degradation contributes to the progression of AAA, the destruction and degradation of elastin fibers caused by an increase in matrix metalloproteinases (MMPs) plays a pivotal role in the development of AAA.
|
15800662 |
2005 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The substantial production of elastin and elastic fibre-like structures that we observed in the AAA neointima, which was not observed elsewhere within AAA tissues, provides a unique opportunity to capitalize on this autoregenerative phenomenon and direct it from the standpoint of matrix organization towards restoring healthy aortic matrix structure, mechanics and function.
|
24799390 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that miR-516a-5p may regulate MTHFR, MMP-2, and TIMP-1 expressions in human VSMCs, possibly promoting the disruption of Hcy metabolism and proteolytic degradation of elastin for AAA formation.
|
28288890 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Histological alterations, including aortic wall thickening, collagen deposition, elastin fragmentation, and vascular smooth muscle cell apoptosis in AAA tissue of ApoE KO mice, were also significantly attenuated in LMP7/ApoE dKO mice.
|
30642978 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The systematic search was performed in two stages: firstly, using the terms AAA and gender/sex/women; and secondly, adding the terms "elastin", "collagen" and "vascular smooth muscle cells", in order to filter the search for studies relevant to our focus on the aneurysm wall.
|
29452784 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Abdominal aortic aneurysms (AAAs) involve slow proteolysis and loss of structural matrix components (collagen and elastin), which lead to wall thinning, weakening and ultimate rupture.
|
25376929 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice.
|
19720934 |
2009 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, we show that this novel targeting technique can be used as a diagnostic tool to predict the degree of elastin damage and therefore rupture potential in AAAs better than the extent of dilation.
|
31281538 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The growth of the AAA is dependent on proteolytic degradation of elastin.
|
17721627 |
2007 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The decreased elastin concentration relative to collagen in AAAs may be explained, in part, by the changes in message level of elastin and collagen.
|
1641765 |
1992 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that polymorphisms in MMP2, MMP3, MMP-13, and ELN genes may independently contribute to the pathogenesis of AAA.
|
22094117 |
2012 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
A2AR activation attenuates AAA formation partly by inhibiting immune cell recruitment and reducing elastin fragmentation.
|
23413358 |
2013 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Degradation of extracellular matrix, especially elastin, within the aortic wall is a hallmark of abdominal aortic aneurysms (AAAs).
|
9588507 |
1998 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Imatinib administration (50 mg/kg/d, i.g.) was carried out one week after the establishment of elastase-induced AAA in rats, stabilizing aneurysm progression and improving survival rate via decreasing the aortic diameter and preventing elastin degradation.
|
31325435 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that destruction of the elastin fiber network during AAA formation is dependent on macrophage-derived MT1-MMP, which unexpectedly serves as a direct-acting regulator of macrophage proteolytic activity.
|
19010778 |
2009 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Smooth muscle cells from abdominal aortic aneurysms are unique and can independently and synergistically degrade insoluble elastin.
|
24080131 |
2014 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
Degradation of the extracellular matrix components elastin and collagen has been implicated in vascular diseases, including abdominal aortic aneurysm (AAA) and atherosclerotic plaque rupture.
|
14681644 |
2003 |
|
Aortic Aneurysm, Abdominal
|
0.400 |
Biomarker
|
disease |
BEFREE |
The evolution of AAAs is thought to involve the progressive degradation of aortic wall elastin and collagen, and increased local production of several matrix metallo-proteinases (MMPs) has been implicated in this process.
|
10415728 |
1999 |