Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation and rupture.
|
31595818 |
2019 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Aortic diameter in the DM+AA group was less than that in the AA group, and elastin fragmentation grade of the aortic wall was reduced in the DM+AA group.
|
31096818 |
2019 |
Aortic Aneurysm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
BM-MSCs and MSCs-CM significantly attenuated matrix metalloproteinase (MMP)-2 and MMP-9 expression, aortic elastin degradation and AA growth at the site of AA.
|
31583844 |
2019 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taking into consideration the continuously ongoing challenges during life, there is a physiological degradation of elastin into elastin-derived peptides which is accentuated in several disease states such as obstructive pulmonary diseases, atherosclerosis and aortic aneurysm.
|
31295577 |
2019 |
Aortic Aneurysm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We used a mouse model of postnatal ascending aortic aneurysms ( Fbln4<sup>SMKO</sup>; termed SMKO [SMC-specific knockout]), in which deletion of Fbln4 (fibulin-4) leads to disruption of the elastin-contractile units caused by a loss of elastic lamina-SMC connections.
|
30355232 |
2018 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interestingly, the elastin-contractile unit, which is an anatomical and functional unit connecting extracellular elastic laminae to the intracellular SMC contractile filaments, via cell surface receptors, has been shown to play a critical role in the mechanosensing of SMCs, and many genes identified in TAAs encode for proteins along this continuum.
|
28943527 |
2018 |
Aortic Aneurysm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
CAM suppressed the progression and rupture of AA through the suppression of inflammatory macrophage infiltration, a reduction in MMP-2 and MMP-9 activity, and the inhibition of elastin degradation associated with the suppression of NF-κB phosphorylation.
|
29550174 |
2018 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm.
|
28385916 |
2017 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
The substantial production of elastin and elastic fibre-like structures that we observed in the AAA neointima, which was not observed elsewhere within AAA tissues, provides a unique opportunity to capitalize on this autoregenerative phenomenon and direct it from the standpoint of matrix organization towards restoring healthy aortic matrix structure, mechanics and function.
|
24799390 |
2017 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
Elastin and collagen fibers were more highly aligned in BAV-NA and BAV-TAA cases than in TAV-TAA cases, whereas TAV-TAA cases were more disorganized than TAV-NA cases.α-Elastin content was unchanged.
|
23764410 |
2014 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
WT TAAs demonstrated elastin fragmentation, smooth muscle cell loss, macrophage infiltration, and increased IL-1β expression.
|
25200056 |
2014 |
Aortic Aneurysm
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous elastin gene mutations cause autosomal dominant cutis laxa associated with emphysema and aortic aneurysms.
|
20600892 |
2010 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
BEFREE |
AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice.
|
19720934 |
2009 |
Aortic Aneurysm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Several investigators have reported reduced elastin content and increased elastase activity in infrarenal aortic aneurysms.
|
8433437 |
1993 |
Aortic Aneurysm
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Collagen and elastin gene expression in aortic aneurysms.
|
1641765 |
1992 |
Aortic Aneurysm
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|