|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elastin fragments (EFs) have been detected in the serum of smokers with emphysema, and elastin-specific T cells have also been detected in the peripheral blood of smokers with emphysema.
|
31182478 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Impact of aging on inflammatory and immune responses during elastin peptide-induced murine emphysema.
|
30675803 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elastin peptides (EP) can induce lung inflammation and emphysema.
|
31819402 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure.
|
31234847 |
2019 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Emphysema is caused by an elastase/anti-elastase imbalance leading to accelerated elastin degradation.
|
29558926 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Chronic obstructive pulmonary disease (COPD) is characterized by high levels of protease activity leading to degradation of elastin followed by loss of elasticity of the lung and the development of emphysema.
|
30017196 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since elastin concentrations are reduced in emphysematous lungs, the factor of divergence between emphysema and fibrosis seems to be the degree of elastin repair.
|
30220340 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
This causes a deficiency of the inhibitor of neutrophil elastase, which results in increased degradation of lung elastin and the development of pulmonary emphysema.
|
29461896 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Findings from experimental models suggest that some MMPs, such as MMP-12, may directly breakdown elastin, whereas others, particularly MMP-10 and MMP-28, promote the development of emphysema by influencing the proteolytic and inflammatory activities of macrophages.
|
29406250 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta.
|
28488348 |
2018 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that type VI collagen turnover and elastin degradation by neutrophil elastase are associated with COPD-induced inflammation (eosinophil-bronchitis) and emphysema.
|
28103932 |
2017 |
|
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chronic obstructive pulmonary disease and emphysema are associated with increased elastin peptides (EP) production because of excessive breakdown of lung connective tissue.
|
28572155 |
2017 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, we show that <i>Vangl2<sup>Lp/+</sup></i> lungs exhibit many of the hallmarks of tissue damage, including an altered macrophage population, abnormal elastin deposition and elevated levels of the elastin-modifying enzyme, <i>Mmp12</i>, all of which are observed in emphysema.
|
28237967 |
2017 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
CTD_human |
A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.
|
25106431 |
2014 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with COPD have increased skin elastin degradation compared with controls, which is related to emphysema severity and arterial stiffness.
|
22374923 |
2012 |
|
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We postulate that hemizygosity at the elastin gene locus may increase susceptibility towards the development of COPD and emphysema in subjects with WBS.
|
20186780 |
2010 |
|
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous elastin gene mutations cause autosomal dominant cutis laxa associated with emphysema and aortic aneurysms.
|
20600892 |
2010 |
|
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mechanical testing demonstrates that lungs with low levels of elastin experience greater tissue strains for any given tissue stress compared with wild-type lungs, implying that force-mediated propagation of lung injury through alveolar wall failure may worsen the emphysema after an initial enzymatic insult.
|
17142349 |
2007 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition to the normal 68 kDa tropoelastin (TE) protein, an abnormal, 120 kDa polypeptide was detected in the proband and her affected daughter in a CL family characterized by hernias and unusually severe and early-onset pulmonary disease including bronchiectasis and pulmonary emphysema.
|
15955094 |
2005 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Through a global analysis of pulmonary gene expression in the lungs of mice lacking this integrin (Itgb6 null mice) we have identified a marked induction of macrophage metalloelastase (Mmp12)--a metalloproteinase that preferentially degrades elastin and has been implicated in the chronic lung disease emphysema.
|
12634787 |
2003 |
|
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
It degrades a variety of extracellular matrix proteins including elastin in vitro and causes emphysema when administered by tracheal insufflation to hamsters.
|
1400430 |
1992 |