ELN, elastin, 2006

N. diseases: 545; N. variants: 61
Disease: Varicosity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042345
Disease: Varicosity
Varicosity 		0.040 AlteredExpression disease BEFREE The up-regulation of elastin expression may play an important role in the pathogenesis of primary varicose veins. 24785109 2014
CUI: C0042345
Disease: Varicosity
Varicosity 		0.040 Biomarker disease BEFREE The total elastin content in varicose as opposed to non-varicose veins is reduced; changes in overall collagen content are uncertain. 19847861 2009
CUI: C0042345
Disease: Varicosity
Varicosity 		0.040 Biomarker disease BEFREE Our results suggest that the screened cDNA clones are useful disease markers in the genetic diagnosis of primary varicose vein and that the L1 and Alu elements possibly participated in the development of primary varicose veins through their expression patterns in genes encoded with structural proteins, such as collagen, elastin, and tropomyosin. 15680382 2005
CUI: C0042345
Disease: Varicosity
Varicosity 		0.040 AlteredExpression disease BEFREE Studies have reported that structural proteins such as elastin and collagen are decreased in varicose veins compared to normal controls. 12175972 2002