EPAS1, endothelial PAS domain protein 1, 2034

N. diseases: 293; N. variants: 35
Disease: Metabolic Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.040 Biomarker group BEFREE Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice. 30709906 2019
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.040 Biomarker group BEFREE These results indicate a regulatory role for HIF-2α in obesity progression and suggest a therapeutic opportunity for PT2399 in obesity and associated metabolic disorders. 30523118 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.040 Biomarker group BEFREE Inhibition of HIF1α and HIF2α decreases the adverse diet-induced metabolic phenotypes, suggesting that they could be drug targets for the treatment of metabolic diseases. 30275460 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.040 Biomarker group BEFREE PT2385, a HIF-2α-specific inhibitor, had preventive and therapeutic effects on metabolic disorders that were dependent on intestine HIF-2α. 29035368 2017