EPAS1, endothelial PAS domain protein 1, 2034

N. diseases: 293; N. variants: 35
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group BEFREE We propose that Spint1 contributes to the tumor-suppressive function of HIF-2α in TAMs in breast tumor development. 31436357 2019
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group BEFREE However, whether Hypoxia-inducible factor-2α (HIF-2α) in hypoxic tumor microenvironment mediates conversion to a stem cell phenotype and chemoresistance of breast tumors has not been elucidated. 30340507 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 AlteredExpression group BEFREE Herein, we outline protocols optimized to detect binding of Hypoxia-Inducible Factor (HIF)-1α or HIF-2α to putative hypoxia response elements (HREs) within HIF target genes expressed in breast tumor epithelial cells. 29330791 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group LHGDN Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer. 19010893 2008