|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Carcinoma of lung
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
EPHA3 has been revealed to be the most frequently mutated Eph receptor gene in lung cancer with abnormal expression.
|
27101199 |
2016 |
|
Carcinoma of lung
|
0.350 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Carcinoma of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
This simple formulation offered high transfection efficiency and negligible cytotoxicity in HEK-293 (a virus-immortalized kidney cell) and A549 (a human lung cancer cell line).
|
26878305 |
2016 |
|
Carcinoma of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
RTA-4D5-KDEL had a strong inhibitory effect on HER2-overexpressing SKOV-3 cells and caused little damage to normal HEK-293 cells and H460 lung cancer cells.
|
30141083 |
2018 |
|
Carcinoma of lung
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
EPHA3 expression levels were determined by quantitative reverse transcription-polymerase chain reaction in paired normal-tumor clinical specimens and by immunohistochemistry in human lung cancer tissue microarrays.
|
22829656 |
2012 |
|
Carcinoma of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
The following procathepsin S species were examined: wild-type procathepsin S in macrophages, recombinant procathepsin S in human embryonic kidney cells (HEK 293 cells), recombinant nonglycosylated procathepsin S in HEK 293 cells, wild-type procathepsin S in the established nonsmall cell lung carcinoma cell line 97TM1.
|
10469135 |
1999 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
The most obvious finding to emerge from the analysis that novel synthesized sulfonamide derivative H-4i is effective on HT-29 more than HEK-293.
|
29520697 |
2018 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our findings reveal the mechanisms underlying the oncogenic activities of EphA3 in colorectal cells, which could provide novel targets for the prevention, early diagnosis, and treatment of colorectal cancer.
|
27721017 |
2016 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
However, the role of EPHA3 in colorectal cancer has not been thoroughly investigated.
|
28169277 |
2017 |
|
Colorectal Carcinoma
|
0.340 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Colorectal Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
A comparison of EphA3 immunohistochemical scores for tumor and matched normal intestinal tissues revealed that the protein was downregulated in 82/164 (50.0%), unchanged in 52/164 (31.7%), and upregulated in 30/164 (18.3%) cases of CRC.
|
30560328 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Moreover, EPHA3 gene copy numbers and/or expression levels were decreased in tumors from large cohorts of patients with lung cancer (eg, the gene was deleted in 157 of 371 [42%] primary lung adenocarcinomas).
|
22829656 |
2012 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We report here a thorough study to address the physiological role of the putative lung cancer tumor suppressor EPH receptor A3 (EPHA3), a gene that is frequently mutated in human lung adenocarcinomas.
|
25713296 |
2015 |
|
Squamous cell carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Paroxysmal atrial fibrillation
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Paroxysmal atrial fibrillation
|
0.300 |
Biomarker
|
disease |
CTD_human |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Large cell carcinoma of lung
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Pancreatic Ductal Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Cleft upper lip
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
|
22863734 |
2012 |
|
Malignant neoplasm of breast
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In an effort to settle the controversy, we tested several stable E1A transfectants of cell lines MDA-MB-231, MCF-7, MDA-MB-435 (breast cancer), SKOV3-ipl (ovarian cancer), and PC-3 (prostate cancer), as well as parental and vector-transfected controls, HEK 293 cells, and RD-ES (Ewing sarcoma) cells, for the EWS-FLI1 fusion product.
|
11051226 |
2000 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
Transfection experiments which overexpressed the full-length EG-1 gene in human embryonic kidney HEK-293 cells or human breast cancer cell lines resulted in significantly increased in vitro proliferation, in comparison with transfection with empty vectors.
|
16024617 |
2005 |