|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
Based on these findings, we have synthesized some new diflunisal thiosemicarbazides and 1,2,4-triazoles and tested them against androgen-independent prostate adenocarcinoma (PC-3), colon carcinoma (HCT-116), human breast cancer (T47D), breast carcinoma (MCF7) and human embryonic kidney (HEK-293) cell lines.
|
30082676 |
2018 |
|
Malignant neoplasm of breast
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
And EPHA3 could be up-regulated by Sam68 in breast cancer.
|
31433759 |
2020 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells.
|
29229759 |
2018 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
YH0618 selectively attenuated DOX-induced growth inhibition and apoptosis in human normal liver L02 cells and kidney HEK-293 cells, and simultaneously potentiated the anti-cancer effect of DOX in breast cancer MCF-7 and MDA-MB-231 cells by apoptosis pathways.
|
31333784 |
2019 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
The in vitro biocompatibility and cytotoxicity tests of these films were also conducted using 3-(4,5-dimethylthiazole-2-yl-2,5-diphenyl tetrazolium bromide) assay of human embryonic kidney (HEK-293) and human breast cancer (MCF-7) cell lines up to 48 h, which shows their biocompatible nature.
|
30556014 |
2018 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
The proteins were added to human breast cancer cells (MDA-MB-231) and human embryonic kidney cells (HEK-293) in order to investigate the characteristic of selective targeting and releasing of scorpion toxin AGAP in cancer cells with high uPAR expression.
|
29172777 |
2017 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
In addition, cell-proliferation inhibition activity for all four ligands on the Human embryonic kidney (HEK-293) and breast cancer cell lines (MCF-7) was performed using MTT assay.
|
27748164 |
2017 |
|
Neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our observations show that HS-2015-BA-01 is more cytopathic than PLCal_ZV in proliferation assays in Vero, Human Embryonic Kidney HEK 293T and neuroblastoma SH-SY5Y cells.
|
29382068 |
2018 |
|
Neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
It showed cytotoxicity to neuroblastoma (SHSY5Y) cell line with IC<sub>50</sub> value < 100 μg ml<sup>- 1</sup> but had least damaging effect on normal cells, like human embryonic kidney (HEK-293) and liver (WRL-68) cell lines.
|
31382946 |
2019 |
|
Neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here we studied vortioxetine's functional effects across species (canine, mouse, rat, guinea pig and human) in cellular assays with heterologous expression of 5-HT<sub>3A</sub> receptors (in Xenopus oocytes and HEK-293 cells) and in mouse neuroblastoma N1E-115 cells with endogenous expression of 5-HT<sub>3A</sub> receptors.
|
29274875 |
2018 |
|
Neuroblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In this study, using radioligand binding assay, immunoblot or immunocytochemistry methods, we observed that SK608 induced internalization of human D3R stably expressed in CHO, HEK and SH-SY5Y cells which are derived from neuroblastoma cells, suggesting that it is not a cell-type specific event.
|
30844536 |
2019 |
|
Neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We compared the subcellular localization of FLAG-epitope tagged Types 1 and 2 deiodinases (D1 and D2) transiently expressed in human embryonic kidney (HEK-293) and mouse neuroblastoma (NB2A) cells.
|
11089566 |
2000 |
|
Neuroblastoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
SK-N-SH (neuroblastoma) and PC-12 (phaeochromocytoma) cells were used and compared with HEK-293 cells transfected with OCT1, OCT2 and OCT3, respectively.
|
19324274 |
2009 |
|
Neuroblastoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed the functional implication of this mutation in the human neuroblastoma cell line BE(2)-C, and non-neural Human Embryonic Kidney 293 (HEK-293), and show that the -220A mutation results in a constitutive increase in the expression of the CALR gene (p<0.0003).
|
21723904 |
2011 |
|
Neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Moreover, in transfected HEK-293T and neuroblastoma SH-SY5Y cells, and in primary neuronal cultures, pretreatment with cocaine or a σ<sub>1</sub>R agonist inhibited ghrelin-mediated signaling, in a similar manner as the GHS-R1a antagonist YIL-781.
|
29876881 |
2019 |
|
Neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We addressed the importance of the DAT molecule for selective dopaminergic toxicity by testing the differential cytotoxicity of 22 neutral and quaternary compounds from three classes of isoquinoline derivatives (3, IQs; 4,3,4-dihydroisoquinolines and 15, 1,2,3,4-tetrahydroisoquinolines) as well as MPP(+) in non-neuronal and neuronal heterologous expression systems of the DAT gene (human embryonic kidney HEK-293 and mouse neuroblastoma Neuro-2A cells, respectively).
|
11911843 |
2002 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
In addition, cell-proliferation inhibition activity for all four ligands on the Human embryonic kidney (HEK-293) and breast cancer cell lines (MCF-7) was performed using MTT assay.
|
27748164 |
2017 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Transfection experiments which overexpressed the full-length EG-1 gene in human embryonic kidney HEK-293 cells or human breast cancer cell lines resulted in significantly increased in vitro proliferation, in comparison with transfection with empty vectors.
|
16024617 |
2005 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The in vitro biocompatibility and cytotoxicity tests of these films were also conducted using 3-(4,5-dimethylthiazole-2-yl-2,5-diphenyl tetrazolium bromide) assay of human embryonic kidney (HEK-293) and human breast cancer (MCF-7) cell lines up to 48 h, which shows their biocompatible nature.
|
30556014 |
2018 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
And EPHA3 could be up-regulated by Sam68 in breast cancer.
|
31433759 |
2020 |
|
Breast Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In an effort to settle the controversy, we tested several stable E1A transfectants of cell lines MDA-MB-231, MCF-7, MDA-MB-435 (breast cancer), SKOV3-ipl (ovarian cancer), and PC-3 (prostate cancer), as well as parental and vector-transfected controls, HEK 293 cells, and RD-ES (Ewing sarcoma) cells, for the EWS-FLI1 fusion product.
|
11051226 |
2000 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We show that overexpression of JMJD6 increased HOTAIR expression and JMJD6 siRNAs suppressed it in ER+ MCF-7, triple negative MDA-MB-231 and non-breast cancer HEK 293 cells.
|
29229759 |
2018 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
YH0618 selectively attenuated DOX-induced growth inhibition and apoptosis in human normal liver L02 cells and kidney HEK-293 cells, and simultaneously potentiated the anti-cancer effect of DOX in breast cancer MCF-7 and MDA-MB-231 cells by apoptosis pathways.
|
31333784 |
2019 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The proteins were added to human breast cancer cells (MDA-MB-231) and human embryonic kidney cells (HEK-293) in order to investigate the characteristic of selective targeting and releasing of scorpion toxin AGAP in cancer cells with high uPAR expression.
|
29172777 |
2017 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Based on these findings, we have synthesized some new diflunisal thiosemicarbazides and 1,2,4-triazoles and tested them against androgen-independent prostate adenocarcinoma (PC-3), colon carcinoma (HCT-116), human breast cancer (T47D), breast carcinoma (MCF7) and human embryonic kidney (HEK-293) cell lines.
|
30082676 |
2018 |