|
Central neuroblastoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In this study, using radioligand binding assay, immunoblot or immunocytochemistry methods, we observed that SK608 induced internalization of human D3R stably expressed in CHO, HEK and SH-SY5Y cells which are derived from neuroblastoma cells, suggesting that it is not a cell-type specific event.
|
30844536 |
2019 |
|
Central neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
It showed cytotoxicity to neuroblastoma (SHSY5Y) cell line with IC<sub>50</sub> value < 100 μg ml<sup>- 1</sup> but had least damaging effect on normal cells, like human embryonic kidney (HEK-293) and liver (WRL-68) cell lines.
|
31382946 |
2019 |
|
Central neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Moreover, in transfected HEK-293T and neuroblastoma SH-SY5Y cells, and in primary neuronal cultures, pretreatment with cocaine or a σ<sub>1</sub>R agonist inhibited ghrelin-mediated signaling, in a similar manner as the GHS-R1a antagonist YIL-781.
|
29876881 |
2019 |
|
Central neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here we studied vortioxetine's functional effects across species (canine, mouse, rat, guinea pig and human) in cellular assays with heterologous expression of 5-HT<sub>3A</sub> receptors (in Xenopus oocytes and HEK-293 cells) and in mouse neuroblastoma N1E-115 cells with endogenous expression of 5-HT<sub>3A</sub> receptors.
|
29274875 |
2018 |
|
Central neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our observations show that HS-2015-BA-01 is more cytopathic than PLCal_ZV in proliferation assays in Vero, Human Embryonic Kidney HEK 293T and neuroblastoma SH-SY5Y cells.
|
29382068 |
2018 |
|
Central neuroblastoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed the functional implication of this mutation in the human neuroblastoma cell line BE(2)-C, and non-neural Human Embryonic Kidney 293 (HEK-293), and show that the -220A mutation results in a constitutive increase in the expression of the CALR gene (p<0.0003).
|
21723904 |
2011 |
|
Central neuroblastoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
SK-N-SH (neuroblastoma) and PC-12 (phaeochromocytoma) cells were used and compared with HEK-293 cells transfected with OCT1, OCT2 and OCT3, respectively.
|
19324274 |
2009 |
|
Central neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We addressed the importance of the DAT molecule for selective dopaminergic toxicity by testing the differential cytotoxicity of 22 neutral and quaternary compounds from three classes of isoquinoline derivatives (3, IQs; 4,3,4-dihydroisoquinolines and 15, 1,2,3,4-tetrahydroisoquinolines) as well as MPP(+) in non-neuronal and neuronal heterologous expression systems of the DAT gene (human embryonic kidney HEK-293 and mouse neuroblastoma Neuro-2A cells, respectively).
|
11911843 |
2002 |
|
Central neuroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We compared the subcellular localization of FLAG-epitope tagged Types 1 and 2 deiodinases (D1 and D2) transiently expressed in human embryonic kidney (HEK-293) and mouse neuroblastoma (NB2A) cells.
|
11089566 |
2000 |