|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Amplification and overexpression of the c-erbB-2/neu gene has been shown in certain human tumors and is postulated to be important in human carcinogenesis.
|
1350198 |
1992 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Amplified expression of p185HER-2, the protein product of the HER-2/neu proto-oncogene, appears to be involved in carcinogenesis of human mammary epithelial cells.
|
1674366 |
1991 |
|
Carcinogenesis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
This is the first report suggesting that c-erb B-2/neu gene amplification may be associated with human bladder carcinogenesis.
|
1978777 |
1990 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Evidence that the c-erbB-2 proto-oncogene is important in prognosis and oncogenesis in a number of human malignancies is increasing.
|
1979342 |
1990 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Tumor development in mice containing the c-myc or c-erbB-2 transgene suggests that the cellular and developmental contexts in which the genes are expressed define their relative contribution to tumorigenesis.
|
2667653 |
1989 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We identified a total of 16 genes, including c-erbB-2 and tissue inhibitor of metalloproteinases 3 whose products have been implicated in tumorigenesis or invasion.
|
7796418 |
1995 |
|
Carcinogenesis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Such a strong association between microsatellite instability and erbB-2 oncogene may be responsible for the increase of other oncogenic mutations and tumor progression in gastric carcinogenesis.
|
7882346 |
1995 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The c-erbB-2 (HER-2/neu) proto-oncogenes is important in oncogenesis and for determination of prognosis in a number of human malignancies.
|
7905629 |
1993 |
|
Carcinogenesis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Since high expression of neu mRNA is evident in the hamster Schwann cell at the late gestational and neonatal stages, transplacental administration of N-nitroso-N-ethylurea is considered to interact directly to carcinogenesis of the hamster Schwann cell through neu gene mutation.
|
7906199 |
1994 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Consistent HER-2/neu overexpression occurs infrequently in early ovarian cancer, making it unlikely that such overexpression is a general early event in ovarian carcinogenesis.
|
7906607 |
1994 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The present study was undertaken to define whether c-myc, int2/FGF3 (11q13 region) and c-erbB2/neu genes are involved in prostate tumorigenesis.
|
7960236 |
1994 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Tl investigate the possible role of c-erbB-2 oncogene in the oncogenesis of stomach cancer, we examined the genetic alterations of c-erbB-2 oncogene in 4 stomach cancer cell lines, SNU-1, SNU-5, SNU-16 and KATO III.
|
8104420 |
1993 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Some oncogenes such as the ras, myc, erbB-2 and abl have been extensively investigated in the progression of carcinogenesis in several types of human tumors.
|
8318905 |
1993 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Differences between phosphotyrosine accumulation and Neu/ErbB-2 receptor expression in astrocytic proliferative processes. Implications for glial oncogenesis.
|
8826951 |
1996 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
HER-2/neu gene expression could not be related to survival differences--perhaps due to overall poor survival within adenocarcinomas of the pancreas--but the pattern of HER-2/neu expression suggests a relationship to glandular differentiation and early oncogenesis.
|
9094152 |
1997 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We have examined the potential role of neu receptor proto-oncogene in human pituitary tumorigenesis.
|
9231056 |
1997 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Here we report that transcripts of PEA3, an ETS transcription factor implicated in oncogenesis, were increased in 93% of HER2/Neu-overexpressing human breast tumor samples.
|
9380403 |
1997 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Some genetic alterations were found accompanying those morphological changes, such as 3p- and activation of c-myc, c-erbB-2 and bcl2, suggesting that those genetic alterations may contribute to the carcinogenesis of human bronchial epithelial cells at an early stage.
|
9493136 |
1998 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that: (a) the amplification produces c-erbB-2 in the HSR form generally early in the carcinogenesis of gastric adenocarcinomas; and (b) in the process of cancer development, the amplified gene is lost in some cancer cells by uneven segregation of HSR in mitosis, whereas in others, it is kept in HSR or translocated to other chromosomal positions, thereby preserving overexpression of c-erbB-2 protein.
|
9520947 |
1998 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Regarding the significantly poorer prognosis of patients with c-erbB-2-positive tumors, we discuss common features and differences between c-erbB-2 oncoprotein overexpression in pregnancy and in carcinogenesis.
|
9681912 |
1998 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This suggests that c-erbB-2 activation plays a certain role, mostly probably during the early stages, in carcinogenesis in oesophageal squamous cell carcinomas from Hong Kong Chinese patients.
|
9800975 |
1998 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This indicates that the formation of an amplicon, in which both the GAS and the ERBB2 genes are amplified, might be unique in gastric cancer, especially in its intestinal type, and that simultaneous amplification of both genes is important to the tumorigenesis of intestinal gastric cancer.
|
9892105 |
1999 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Data indicate a central role for ErbB-2 in mediating the responses induced by these ligands and suggest that these altered ligand-dependent responses play an important role in tumorigenesis in vivo.
|
9935193 |
1999 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The amplification and overexpression of the erbB-2 oncogene and its involvement in tumorigenesis makes this receptor an appropriate target for specific agents directed towards tumor cells.
|
10515198 |
1999 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The high incidence of p53, HER-2/neu and c-myc overexpression in fallopian tube adenocarcinoma suggests these genes may play a role in its tumorigenesis.
|
10629373 |
2000 |