|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis.
|
10655108 |
2000 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Other cancer-related genes (including myc, c-erbB2, Tsg101 and Mdgi) are involved in breast carcinogenesis, but they do not give rise to familial breast cancer syndromes.
|
10671920 |
2000 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The purpose of this study was to analyse erbB-1 and erbB-2 oncogenes in non-dysplastic oral leukoplakia to see if we could pinpoint the first steps towards dysplasia and possible carcinogenesis.
|
10687911 |
1999 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Alterations of the HER2 (also known as erbB-2 or neu) proto-oncogene have been implicated in the carcinogenesis and prognosis of breast cancer.
|
10699071 |
2000 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The results of this study suggest that c-erbB2 overexpression without amplification may occur early in breast oncogenesis.
|
10861572 |
2000 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Mice harboring dual transgenes encoding TGFalpha and either wild-type ERBB2 or c-myc displayed markedly accelerated tumorigenesis compared to mice carrying any of the single transgenes alone, indicative of potent cooperativity.
|
10882298 |
1997 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
PEA3, a member of the Ets family of transcriptional regulatory proteins, is expressed in a unique spatial and temporal pattern during mouse embryogenesis; its overexpression is positively correlated with HER2-mediated breast tumorigenesis in both humans and mice.
|
11094084 |
2000 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of the tyrosine kinase HER2/neu is observed in many human breast cancers and is positively correlated with enhanced tumorigenesis.
|
11250739 |
2001 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that the CCND1 gene plays an early role and the ERBB2 gene a later role in thyroid tumorigenesis.
|
11288983 |
2001 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
HER-2/neu (ERBB2) gene amplification and/or overexpression is a major event in human breast tumorigenesis.
|
11371225 |
2001 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The importance of alterations of the Her-2/neu oncogene in the tumorigenesis of Barrett's adenocarcinoma (BCA) is discussed controversially.
|
11406641 |
2001 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Although the activity of the HER receptor is strictly controlled in normal cells, HER2 receptor overexpression plays a pivotal role in transformation and tumorigenesis.
|
11521729 |
2001 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The mechanisms leading to transformation and tumorigenesis of HER2/neu-overexpressing cells will also be addressed.
|
11706403 |
2001 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Whether PEA3 plays an essential role in HER2/Neu-mediated oncogenesis has heretofore not been addressed.
|
11719215 |
2001 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Our data suggest that amplification of Her-2/neu appears to be mainly involved in initiation of breast oncogenesis and that its role in progression of breast cancers is uncertain.
|
11850540 |
2002 |
|
Carcinogenesis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Alterations of the HER-2 gene have been implicated in the carcinogenesis and prognosis of breast cancer and other solid tumors.
|
12166652 |
2002 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The observed discrepancy in the pattern of the human oncogenes CCND1 and ERBB2, which are involved in the process of carcinogenesis of ductal tumors, appears to suggest a different molecular basis for development and progression of ILC.
|
12203362 |
2002 |
|
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
It has been implicated in mammary carcinogenesis through its regulation of HER-2/neu proto-oncogene and estrogen receptor gene The hAP-2gamma gene is located on human chromosome 20q13.2.
|
12490322 |
2002 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
|
12810676 |
2003 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, this analysis has revealed several transcription factors that may be involved in ErbB2-mediated tumorigenesis.
|
12941816 |
2003 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Alterations of the HER-2 (erbB-2/neu) proto-oncogene have been associated with carcinogenesis and poor prognosis of certain cancers.
|
14520697 |
2003 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that siRNA may be an effective method of abrogating the effect of HER2 in tumorigenesis.
|
14618618 |
2004 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The statistically significant difference (P < 0.005) between HER-2/neu alteration in tumor samples(25/131, 19%) and in the nonneoplastic tissue (0/34, 0%) implies that HER-2/neu may have a role in the carcinogenesis of NSCLC.
|
14639106 |
2003 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Collectively, the introduction of either c-erbB-2 or mutant Ha-ras in the cells, which were efficiently immortalized by the transfection of LT and hTERT, showed tumorigenicity, suggesting that c-erbB-2 or mutant Ha-ras genes might be involved in ovarian carcinogenesis.
|
14676809 |
2003 |
|
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Our data suggest that E6/E7 cooperate with ErbB-2 in head and neck carcinogenesis, at least in part, via the conversion of beta-catenin from a cell adhesion to a nuclear function, that is, to act as a potential transcriptional regulator.
|
14724563 |
2004 |