|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The sarcoma component showed 2+, equivocal HER2 expression in five cases, one of which also demonstrated HER2 amplification by FISH.
|
31477811 |
2020 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HER2 FISH analyses revealed that all transferred-tissue fragments were adequate for determining HER2 amplification.
|
30653031 |
2020 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
NACT can change the status of ER, PgR, and Ki-67 expression in patients with breast adenocarcinoma, but it did not exert a significant effect on HER-2 status; HER-2 amplification appears to be more stable.
|
31754747 |
2020 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We develop here a high-content, quantitative analysis of breast cancer tissues based on microfluidic experimentation and image processing, to characterize both HER2 protein overexpression and HER2 gene amplification at the cellular level.
|
30659272 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the 425 patients with invasive breast cancer, no statistical difference was observed between HER2/SCEP17 and HER2/CEP17 when detecting HER2 gene amplification (P=0.157).
|
31410164 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
A literature review of the prevalence of HER2 amplification in EMPD and the efficacy of HER2-targeted therapy was also undertaken.
|
30854041 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined mRNA expression of androgen receptor (AR), AR splice variant-7, intratumoral androgen synthesis enzyme-encoding genes AKR1C3, CYP17A1, SRD5A1 and SRD5A2, AR protein expression, ERBB2 (HER2) gene amplification and DNA mutations in driver genes.
|
31745978 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of HER-2 protein was highly correlated with HER-2 gene amplification (r = 1.262; p < 0.05).
|
30585768 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
HER2 gene amplification was observed in 35% of ER(+) and HER2 protein-overexpressing specimens, significantly lower than the 94% in ER-negative (ER-) and HER2 protein-overexpressing specimens (P<0.001).
|
31192864 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approximately 20% of breast cancer patients exhibit ErbB2/HER2 gene amplification on chromosome 17q.
|
30500458 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrated that HER2 inhibition is a promising therapeutic strategy for GBC with HER2 amplification and, combined with lapatinib, it can effectively target brain metastasis.
|
31106632 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
The anti-HER2 antibody trastuzumab is standard care for advanced esophagogastric (EG) cancer with <i>ERBB2</i> (HER2) amplification or overexpression, but intrinsic and acquired resistance are common.
|
30463996 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of <i>ERBB2</i> (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort.
|
31019892 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The specific frequency and prognostic role of HER2 protein expression and HER2 gene amplification in those rectal cancers has not been fully investigated.
|
30772061 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously reported the microfluidic-based HER2 (human epidermal growth factor receptor 2) detection in breast carcinomas to greatly correlate with the HER2 gene amplification level.
|
31267199 |
2019 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinically, S310F is most frequent among HER2 extracellular domain mutations and patients with the S310F mutation without HER2 amplification responded to trastuzumab with or without the pertuzumab combination.
|
31635022 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis.
|
31805897 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
HER2 amplification is detected in 3% of patients with colorectal cancer (CRC), making tumors in the metastatic setting vulnerable to double pharmacological HER2 blockade.
|
30952821 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FISH confirmed homogeneous ERBB2 amplification in a tumor showing HER2 protein expression heterogeneity.
|
31115453 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
CTC with HER2 amplification can be detected in a limited subset of HER2-negative MBC patients.
|
31727113 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to a few FDA-approved methods such as immunohistochemical (IHC) detection of HER2 protein expression and in situ hybridization (ISH) assessment of HER2 gene amplification, several novel methods have been developed for HER2 testing in recent years.
|
31331487 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that there is a clinical subtype in breast cancer with high HER2 amplification and intact PI3K pathway that is especially sensitive to HER2-targeted therapies without chemotherapy.
|
30903140 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results thus suggest that [fam-] trastuzumab deruxtecan warrants further study as a potential treatment for CRC tumors that express HER2 protein in the absence of HER2 amplification.
|
31087550 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pCR rate among patients with HER2 protein overexpression (IHC 3+) was 67%, compared to 17% among patients with HER2 amplification by FISH (IHC < 3+).
|
31144151 |
2019 |
|
HER2 gene amplification
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Secondly, HER2-enriched subtype can have a distinctive transcriptional landscape independent of HER2 amplification.
|
31737566 |
2019 |