ERBB4, erb-b2 receptor tyrosine kinase 4, 2066

N. diseases: 317; N. variants: 75
Disease: Abnormal behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.060 Biomarker phenotype BEFREE Like ErbB4 KO mice, NRG2 KOs performed abnormally in a battery of behavioral tasks relevant to psychiatric disorders. 28322273 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.060 Biomarker phenotype BEFREE As both NRG1 and ErbB4 are risk genes for schizophrenia, our study may shed new light on the pathophysiology of this disorder and help to improve treatments for psychiatric disorders such as PTSD. 28675393 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.060 Biomarker phenotype BEFREE These subclinical cortical variations may provide early indicators for increased risk of psychiatric disorders and improve our understanding of the effect of the NRG1-ERBB4 pathway on brain development. 25744101 2015
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.060 Biomarker phenotype BEFREE Notably, other disease-associated genes such as BDNF and ERBB4 implicate specific interneuron synapses in psychiatric disorders. 24870235 2014
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.060 Biomarker phenotype BEFREE Our data provide insight into a mechanism of ErbB4 association with schizophrenia; reveal a previously unidentified biological and disease link between NRG1-ErbB4, p110δ, and AKT; and suggest that p110δ is a previously undescribed therapeutic target for the treatment of psychiatric disorders. 22689948 2012
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.060 Biomarker phenotype BEFREE No significant association between ErbB4 and the two other psychiatric disorders was observed, nor did haplotype analysis reveal any positive signal. 21993442 2012