|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that ERCC-1 was involved in the resistance of cetuximab combined with DDP as overexpression of ERCC-1 prohibits the activation of EGFR pathway, which would facilitate the preselection of lung cancer patients for the treatment of cetuximab combined with DDP.
|
20009541 |
2009 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using a panel of 20 lung cancer cell lines, including 15 NSCLC and 5 small cell lung cancers (SCLC), the mRNA expression levels for the RRM1, ERCC1 and ERCC2 genes were examined by quantitative real-time reverse transcription PCR.
|
18494946 |
2008 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested whether genetic variants in the ERCC1 gene are associated with susceptibility to lung cancer and efficacy of platinum-chemotherapy in patients with small cell lung cancer (SCLC).
|
18451256 |
2008 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression of excision repair cross-complementation group 1 (ERCC1) protein in 90 completely resected lung cancer samples from patients who received adjuvant or neo-adjuvant platinum-based chemotherapy.
|
18395930 |
2008 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The haplotype at chromosome 19q13.2-3 encompassing the three SNPs ASE-1 G-21A, RAI IVS1 A4364G and ERCC1 Asn118Asn have been associated with risk of breast cancer and lung cancer.
|
18289367 |
2008 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes, focusing on xeroderma pigmentosum group A (XPA), excision repair cross complementing group 1 (ERCC1), ERCC2/XPD, ERCC4/XPF and ERCC5/XPG.
|
17299578 |
2007 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that ERCC1 polymorphisms may contribute to the etiology of lung cancer.
|
17502833 |
2007 |
|
Carcinoma of lung
|
0.600 |
Biomarker
|
disease |
BEFREE |
DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer.
|
17314339 |
2007 |
|
Carcinoma of lung
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using immunohistochemistry in resected tumors, the International Adjuvant Lung Cancer Trial showed that high ERCC1 protein expression was associated with improved survival in patients who did not receive chemotherapy.
|
17534174 |
2007 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study.
|
16690207 |
2007 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that ERCC1 Asn118Asn (G19007A) polymorphism may play a limited role for lung cancer in this Chinese population.
|
16364765 |
2006 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study indicated no association between mRNA expression of the DNA-repair genes ERCC1 and XPD and risk of subsequent development of lung cancer.
|
16054657 |
2006 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have previously reported that both homozygote carriers of the A-allele as well as homozygous carriers of a high-risk haplotype (which includes the AA genotype in ERCC1 G19007A) were at increased risk of basal cell carcinoma, breast cancer, and lung cancer among Caucasians.
|
16341770 |
2005 |
|
Carcinoma of lung
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There was no overall association between ERCC1 polymorphisms and lung cancer risk, with the adjusted odds ratios (AOR) of 1.26 [95% confidence interval (95% CI), 0.81-1.96] for the 8092C > A polymorphism (A/A versus C/C) and 0.93 (95% CI, 0.67-1.30) for the 19007T > C polymorphism (C/C versus T/T).
|
15734977 |
2005 |
|
Carcinoma of lung
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Carcinoma of lung
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|