|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.
|
28514298 |
2017 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma.
|
26843108 |
2017 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population.
|
27323065 |
2016 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant association was observed between ERCC2 rs13181 polymorphisms and glioma risk.
|
25867436 |
2015 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis strongly suggested that ERCC2 rs13181 was associated with a higher susceptibility to glioma in the Chinese population.
|
26505408 |
2015 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence that DNA repair genes ERCC1, ERCC2, and XRCC1 might be low-penetrance glioma-risk genes, while MGMT and PARP1 polymorphisms may confer protection against glioma.
|
24500421 |
2014 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of this meta-analysis indicate that the AA genotype of ERCC1 C8092A may be associated with a higher risk of adult glioma than the CA and CC genotypes and that the risk allele of ERCC2 K751Q confers a significant susceptibility to adult glioma, especially in Asian populations.
|
24254311 |
2014 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For ERCC2 Lys751Gln polymorphism, no significant association was found between ERCC2 Lys751Gln polymorphism and the risk of glioma in different genetic models.
|
24763305 |
2014 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Crude pooled odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were used to estimate the association between ERCC2 polymorphisms and glioma risk under a suitable effect model according to heterogeneity.
|
24969862 |
2014 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of single-nucleotide polymorphisms in ERCC1 and ERCC2 with glioma risk.
|
24782032 |
2014 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we observed that the XPD 751Gln/Gln genotype is associated with glioma susceptibility, and ERCC1 118 T/T and XPD 751Gln/Gln genotypes confer a significantly better prognosis.
|
22938460 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Single nucleotide polymorphisms and expression of ERCC1 and ERCC2 vis-à-vis chemotherapy drug cytotoxicity in human glioma.
|
17151930 |
2007 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped constitutive variants ERCC1 C8092A and ERCC2 K751Q and R156R in approximately 450 adults with glioma and 500 controls from two independent population-based series, uniformly reviewed patients' tumors to determine histopathologic category, and determined a variety of tumor markers among astrocytic tumors.
|
16212814 |
2005 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the pattern of association observed here is consistent with a role of ERCC2 variants in the prevention or causation of glioma, these results are also consistent with the possibility that another gene linked to ERCC2 may be involved.
|
11319176 |
2001 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Abnormalities in copy number of ERCC1 and ERCC2 are common in glial tumors.
|
8583241 |
1995 |