AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE We conclude AKT1 is less likely to be a vulnerability gene in BD. 31810747 2020
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 AlteredExpression disease BEFREE We propose that the activation of ERK, AKT, and NFκB, resulting from ECS-Na⁺, K⁺-ATPase interaction, modifies neuronal activity and neurotransmission which, in turn, participate in the regulation of behavior and BD. 30087257 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder. 29484683 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE Network analysis showed that although the pathway structure of the epitopes was broadly preserved across the clinical groups, there were multiple discrete alterations in network connectivity, such as disconnections within the antigen/integrin receptor pathway and increased negative regulation within the Akt1 pathway in CD4<sup>+</sup> T cells from ASC and SCZ patients, in addition to increased correlation of Stat1 (pY701) and Stat5 (pY694) responses in B cells from BD and MDD patients. 30038233 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE Overall, the results reinforce a role for AKT1 and mTOR in the pathophysiology of BD and support the relevance of blood mRNA expression as a valid surrogate biological source to study brain intracellular signaling cascades changes and convergent molecular pathways in psychiatric disorders. 25726893 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 GeneticVariation disease BEFREE In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD). 22277669 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD). 22277669 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them. 20214684 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them. 20214684 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE AKT1, encoding the protein kinase B, has been associated with the genetic etiology of schizophrenia and bipolar disorder. 19051289 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET We evaluated the contribution of AKT1 to quantitative cognitive traits and 3D high-resolution neuroanatomical images in a Finnish twin sample consisting of 298 twins: 61 pairs with schizophrenia (8 concordant), 31 pairs with bipolar disorder (5 concordant) and 65 control pairs matched for age, sex and demographics. 19051289 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET In a two-phase study, we evaluated the effect of five promising candidate genes for psychotic disorders, DAOA, COMT, DTNBP1, NRG1, and AKT1, on bipolar spectrum disorder, psychotic disorder, and related cognitive endophenotypes in a Finnish family-based sample ascertained for bipolar disorder. 18466879 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease PSYGENET Transmission of haplotypes constructed from this cluster showed a weak evidence of association between the AKT1 and bipolar disorder. 12618287 2003
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.390 Biomarker disease BEFREE Transmission of haplotypes constructed from this cluster showed a weak evidence of association between the AKT1 and bipolar disorder. 12618287 2003