|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species.
|
31835877 |
2019 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib.
|
29251327 |
2018 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cholangiocarcinoma growth is associated with nuclear export of P27 that is due to AKT-mediated phosphorylation of P27 at T157.
|
29428513 |
2018 |
|
Cholangiocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to investigate the functions of 14-3-3ζ in cholangiocarcinoma (CCA) progression and elucidate the molecular mechanism of 14-3-3ζ expression-mediated protein kinase B (Akt) phosphorylation and chemosensitivity in CCA cells.
|
29387222 |
2018 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
M3 muscarinic acetylcholine receptors regulate epithelial-mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway.
|
30450012 |
2018 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell.
|
30400838 |
2018 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA UCA1 indicates an unfavorable prognosis and promotes tumorigenesis via regulating AKT/GSK-3β signaling pathway in cholangiocarcinoma.
|
29221199 |
2017 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma.
|
26260613 |
2015 |
|
Cholangiocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of the IL-33/ILC2/IL-13 circuit in a murine biliary injury model promoted epithelial repair; however, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts induced cholangiocarcinoma with liver metastases.
|
24892809 |
2014 |
|
Cholangiocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the activation of the AKT/mTOR pathway in CC cell lines with different degrees of dedifferentiation and found that rapamycin could suppress the motility and the peritoneal dissemination of sarcomatoid SCK cells.
|
22875246 |
2013 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma.
|
22735632 |
2012 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In SCID mice with tumor xenografts, mPGES-1 overexpression accelerated tumor formation and increased tumor weight (P<.01), whereas mPGES-1 knockdown delayed tumor formation and reduced tumor weight (P<.01). mPGES-1 inhibited the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to activation of the epidermal growth factor/phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways in cholangiocarcinoma cells. mPGES-1-mediated inhibition of PTEN is regulated through blocking of early growth response-1 sumoylation and binding to the 5'-untranslated region of the PTEN gene.
|
21354147 |
2011 |
|
Cholangiocarcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
|
17461449 |
2007 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
|
17461449 |
2007 |
|
Cholangiocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, our analysis of human CC detected PTEN inactivation in a majority of p-AKT-positive CCs, while about half also lost SMAD4 expression.
|
16767220 |
2006 |
|
Cholangiocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunoblotting showed that Akt is expressed and constitutively phosphorylated in 3 human cholangiocarcinoma lines.
|
15940637 |
2005 |
|
Cholangiocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
|
15150102 |
2004 |