ERF, ETS2 repressor factor, 2077

N. diseases: 131; N. variants: 15
Disease: Skin callus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376154
Disease: Skin callus
Skin callus 		0.010 AlteredExpression disease BEFREE In this study, we demonstrate that WIND1 promotes callus formation and shoot regeneration by upregulating the expression of the <i>ENHANCER OF SHOOT REGENERATION1</i> (<i>ESR1</i>) gene, which encodes another AP2/ERF transcription factor in <i>Arabidopsis thaliana</i> The <i>esr1</i> mutants are defective in callus formation and shoot regeneration; conversely, its overexpression promotes both of these processes, indicating that ESR1 functions as a critical driver of cellular reprogramming. 28011694 2017