Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (pPNET) with a t(15;22) translocation.
|
10209495 |
1998 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias.
|
21519790 |
2011 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumors (PNETs) are associated with a chromosomal translocation resulting in a fusion of the amino-terminus of EWS with the DNA-binding domain of an ETS transcription factor (most commonly FLI1 or ERG).
|
12557222 |
2003 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively.
|
9496833 |
1998 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Greater than 95% of pPNETs carry t(11;22) or t(21;22) chromosomal translocations which fuse the EWS gene from chromosome 22q12 in-frame with either FLI1 from chromosome 11q24 or ERG from chromosome 21q22.
|
7882340 |
1995 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most Ewing tumors (ET), including Ewing sarcomas, peripheral primitive neuroectodermal tumors (PNET), and Askin's tumors, can be defined according to the specific chromosomal translocations t(11;22)(q24;q12) (EWS-FLI-1) or t(21;22)(q21;q12) (EWS-ERG).
|
9646032 |
1998 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pPNETs show t(11;22)(q24;q12) or t(21;22)(q22;q12) chromosomal translocations fusing the EWS gene from 22q12 with either the FL11 gene on 11q24 or the ERG gene on 21q22.
|
8577710 |
1996 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aims of this study were (1) to present the diverse clinicopathological and molecular profile of EFTs in our settings, (2) to identify a pragmatic approach for diagnosing EFTs, especially for application of ancillary techniques, namely RT-PCR for specific transcripts (EWS-FLI1, EWS-ERG) and FISH for EWSR1 gene rearrangement, in certain cases and (3) to show the utility of tissue microarray in establishing a new FISH test.
|
24293381 |
2014 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cytogenetic hallmark of the Ewing family of tumors is t(11,22)(q24;q12) in its simple, complex or variant forms and/or its molecular equivalent EWS/FLI, EWS/ERG rearrangement.
|
9049824 |
1997 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The detection of the EWS-FLI1 (20/25) and EWS-ERG (4/25) fusion transcripts resolved 24 of 25 cases of Ewing sarcoma/PNET.
|
20231617 |
2010 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The method might also accurately diagnose ET-associated translocations other than EWS-FLI and EWS-ERG translocations.
|
11471459 |
2001 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of specific EWS-FLI1 or EWS-ERG transcripts in peripheral blood (PB) samples of patients being treated for ET was prospectively evaluated, and these data were correlated to their clinical status.
|
9836070 |
1998 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To apply these molecular markers to commonly available archival materials, we evaluated the feasibility of detecting EWS-Ets including EWS-Fli1 and EWS-ERG fusion transcripts in paraffin-embedded tissues and its diagnostic value for detecting ES/pPNET.
|
16157025 |
2005 |
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We detected 2 types of EWS-ERG chimeric mRNA in 2 ES cell lines and 1 PNET tumor sample in addition to 4 types of EWS-FLI-1 chimeric mRNA in 11 ESs (4 cell lines and 7 tumor samples) and 4 PNETs (2 cell lines and 2 tumor samples).
|
7591257 |
1995 |