ERG, ETS transcription factor ERG, 2078

N. diseases: 298; N. variants: 31
Disease: Familial lichen amyloidosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 GeneticVariation disease BEFREE We interrogated 54 unsuspected PCA tumors using fluorescence in-situ hybridization for ERG rearrangements and PTEN deletions. 21178509 2011
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 GeneticVariation disease BEFREE If we consider the high incidence of PCA and the high frequency of this gene fusion, TMPRSS2-ERG is the most common genetic aberration so far described in human malignancies. 17527075 2007
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 GeneticVariation disease BEFREE The T-allele of the Met160Val variant in TMPRSS2, which has been associated with the TMPRSS2-ERG fusion, may be informative of time to PCA diagnosis for a subset of high-risk Caucasian men who are undergoing regular PCA screening. 20735386 2011
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 GeneticVariation disease BEFREE The incidences of ERG rearrangements and PTEN deletions in PCA were significantly higher than in high-grade prostatic intra-epithelial neoplasia (HGPIN) and benign prostate tissue (P < 0.001). 20590547 2011
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 GeneticVariation disease BEFREE Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and serine protease inhibitor Kazal type 1 (SPINK1) overexpression were investigated as potential markers for molecularly subtyping prostate cancer (PCA). 22260502 2012
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 GeneticVariation disease BEFREE Regional biases in the presentation of a well-known TMPRSS2-ERG fusion was noted in one PCA and the somatic mutation- and copy number-based phylogenetic relationships between intratumoural biopsies were largely concordant. 24870262 2014
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE Data on TMPRSS2-ERG and AR-V7 may pave the way for personalised therapy for prostate cancer (PCa) patients. 26070514 2016
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE We sought to characterize the incidence, pathological features and clinical parameters of TMPRSS2-ERG gene fusion in a cohort of 196 Canadian men treated by radical prostatectomy for localized PCA, and to investigate its potential as a biomarker in PCA. 19029822 2009
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE AMACR expression was investigated in a cohort of 218 men with localized PCA treated by radical prostatectomy and correlated with ERG and various clinical and pathological parameters. 27271990 2016
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE However, its relation to PTEN and ERG in localized PCA remains unclear. 27738792 2017
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management. 24516518 2014
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE These results indicate that PTEN loss occurs in cooperation with TMPRSS2-ERG fusion in PCA. 26424596 2016
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 Biomarker disease BEFREE An ERG-like 10-gene signature was identified and validated in PCA cohorts of the physician health study (p115) (n = 110) in addition to three independent public datasets, and was significantly associated with disease progression, biochemical recurrence and PCA-specific mortality. 24006850 2014
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 AlteredExpression disease BEFREE Approximately 50% of prostate cancer (PCa) patients in Western countries harbor ERG rearrangement with concurrent ERG overexpression. 24435928 2014
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 AlteredExpression disease BEFREE ERG protein expression was investigated in a cohort of 312 men with PCA diagnosed in transurethral resection of the prostate. 22300588 2012
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 AlteredExpression disease BEFREE Functional biology analysis documented phenylalanine metabolism as the most significant pathway governing high CRISP3 and ERG expression in this subtype of PCA. 24606912 2014
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 AlteredExpression disease BEFREE A striking observation was that ERG and ETV-1 were found to be up-regulated in the glands of the PZ compared to the TZ, particularly when considering that ERG and ETV-1 fusions account for 50-80% and 20% of PCA occurrences, respectively. 22038307 2012
CUI: C0268398
Disease: Familial lichen amyloidosis
Familial lichen amyloidosis 		0.100 AlteredExpression disease BEFREE Chromosomal translocations that juxtapose the androgen-sensitive transmembrane protease, serine 2 (TMPRSS2) gene promoter to the oncogenic ETS-family transcription factor ERG result in excessive ERG overexpression in approximately 50% of prostate cancer (PCa) patients. 24186205 2014