|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite these similarities, Ewing-like sarcomas lack the pathognomonic molecular hallmark of Ewing sarcoma: A translocation between a gene of the RNA-binding TET family (EWSR1 or FUS) with a gene of the ETS-transcription family ( FLI1, ERG, ETV1, ETV4, or FEV).
|
30257034 |
2019 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Three novel fusions were identified: a complex rearrangement involving three genes (EWSR1/RBFOX2/ERG) in Ewing sarcoma, a EWSR1/TCF7L2 fusion in a colon adenocarcinoma, and a EWSR1/TFEB fusion in a translocation-associated renal cell carcinoma.
|
31430493 |
2019 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
EWS/FLI1 and EWS/ERG were found in a transcriptional complex with BRD4, and knockdown of BRD2/3/4 significantly impaired the oncogenic phenotype of EWS cells.
|
29898995 |
2018 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, tumor from a patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) loss and FUS-ERG fusion was implanted in the right chest wall of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model.
|
27286459 |
2016 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
During this investigation we came across a number of ERG-rearranged ES lacking both EWSR1 and FUS abnormalities by FISH.
|
26690869 |
2016 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is illustrated by a case previously thought to represent an atypical carcinoid tumor, in which an EWSR1-ERG translocation was detected during next generation sequencing using a hybrid capture approach, leading to a revised diagnosis of Ewing sarcoma.
|
25441687 |
2015 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
All ES expressed CD99 and FLI1, while ERG positivity was only seen in EWSR1-ERG fusion positive ES.WT1 was negative in all ES.
|
24723486 |
2014 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We therefore evaluated the translational potential of potent and specific LSD1 inhibition with HCI2509 on the transcriptional program of both EWS/FLI and EWS/ERG as well as the downstream oncogenic phenotypes driven by EWS/ETS fusions in both in vitro and in vivo models of Ewing sarcoma.
|
24963049 |
2014 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A characteristic molecular finding in ES is EWSR1 gene fusion with ETS (erythroblast transformation-specific) family genes including FLI1 (~90%) and ERG (>5%).
|
23706910 |
2013 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma.
|
22766791 |
2012 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first report of a EWSR1-ERG fusion in an ES tumor with an apparently duplicated 5' portion of EWSR1, and with a complex translocation involving chromosomes 1, 7, and 21.
|
20633768 |
2010 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although Ewing's sarcoma and AML have known rearrangements rarely involving ERG, we hypothesize that the ERG rearrangement as well as the distinct deletion site on 21q22.2-3 between TMPRSS2 and ERG are prostate-cancer-specific genomic alterations.
|
20473283 |
2010 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, molecular analyses failed to show the presence of the EWS/FLI-1 and EWS/ERG fusion transcripts, indicative of the most common translocations, i.e., t(11;22)(q24;q12) and t(22;21)(q22;q12), occurring in this tumor family.
|
19243895 |
2009 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The significance of these findings and their relationship to other reports of variant and complex ES translocations involving the ERG gene are reviewed.
|
18295659 |
2008 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Standard cytogenetic analyses and RT-PCR testing for the classic gene rearrangements seen in RMS [t(2;13)-PAX3/FKHR] and EWS ([t(11;22) & t(21;22)-EWS/FLI-1 & EWS/ERG), were used for characterization of the MEM, with gene expression microarray analyses on all tumor types.
|
17431644 |
2007 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma.
|
16303180 |
2006 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
All of the fusion genes reported to date in Ewing's tumors juxtapose the EWS gene at 22q12 to an ETS-related gene, the most common of which are FLI1 at 11q24 and ERG at 21q22.
|
12907633 |
2003 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumors (PNETs) are associated with a chromosomal translocation resulting in a fusion of the amino-terminus of EWS with the DNA-binding domain of an ETS transcription factor (most commonly FLI1 or ERG).
|
12557222 |
2003 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fine-mapping of cytogenetically undetectable EWS/ERG fusions on DNA fibers of Ewing tumors.
|
11474174 |
2001 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We selected 30 cases of Ewing's sarcoma with the EWS-ERG gene fusion and 106 cases with the EWS-FLI1 fusion.
|
10561219 |
1999 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The FUS (TLS)-ERG chimeric protein associated with t(16;21)(p11;q22) acute myeloid leukemia is structurally similar to the Ewing's sarcoma chimeric transcription factor EWS-ERG.
|
10523652 |
1999 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively.
|
9496833 |
1998 |
|
Ewings sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Molecular diagnosis of Ewing tumors: improved detection of EWS-FLI-1 and EWS-ERG chimeric transcripts and rapid determination of exon combinations.
|
9646032 |
1998 |
|
Ewings sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Using fluorescence in situ hybridization (FISH) on interphase nuclei or metaphases, we report here the characterization of particular karyotypes in Ewing tumors, namely a complex t(2;11;22) translocation, a variant t(12;22) translocation, and one Ewing tumor without specific rearrangements but with an EWS/ERG fusion gene demonstrated by molecular analysis.
|
9242212 |
1997 |
|
Ewings sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma.
|
9071576 |
1997 |