ESR1, estrogen receptor 1, 2099

N. diseases: 1101; N. variants: 185
Disease: Osteopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.500 AlteredExpression disease BEFREE Bone loss in these patients may be due to deficient ER-alpha protein expression. 10773580 2000
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.500 Biomarker disease BEFREE These results demonstrate that the prevention from the ovariectomy-induced bone loss by estrogen is mediated by ER pathways and that the maintenance of BMD before ovariectomy might be compensated by other mechanisms distinct from ERalpha and ERbeta pathways. 10806217 2000
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.500 Biomarker disease BEFREE The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. 9275080 1997
CUI: C0029453
Disease: Osteopenia
Osteopenia 		0.500 Biomarker disease HPO