Coronary Arteriosclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively, these data revealed that Catalpol inhibited apoptosis and oxidative stress in glucose-deprived H9c2 cell through promoting cell mitophagy and modulating estrogen receptor, supporting the notion that Catalpol could be a novel drug candidate against myocardial ischemia for the treatment of cardiovascular diseases.
|
28292026 |
2017 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Correlation between polymorphisms in the estrogen receptor α gene and coronary heart disease: A meta-analysis.
|
27706721 |
2016 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies.
|
24599688 |
2014 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the association of the rs2234693 and rs9340799 polymorphisms of estrogen receptor alpha gene with coronary heart disease risk in Chinese Han population.
|
23471591 |
2013 |
Coronary Arteriosclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
There was significant enrichment of ESR1 binding present in multiple datasets near genomic regions associated with breast cancer (7.45-fold, p = 0.001), height (2.45-fold, p = 0.002), multiple sclerosis (5.97-fold, p < 0.0002) and prostate cancer (4.47-fold, p = 0.0008), and suggestive evidence of ESR1 enrichment for regions associated with coronary artery disease, ovarian cancer, Parkinson's disease, polycystic ovarian syndrome and testicular cancer.
|
24171864 |
2013 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population.
|
22284250 |
2012 |
Coronary Arteriosclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Post-genomic update on a classical candidate gene for coronary artery disease: ESR1.
|
21984528 |
2011 |
Coronary Arteriosclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To test whether estrogen receptor polymorphisms modify the effects of postmenopausal hormone therapy on biomarkers and on risk of coronary heart disease events, stroke, or venous thromboembolism.
|
21106950 |
2011 |
Coronary Arteriosclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Modulation of gene expression by Polyalthia longifolia in postmenopausal women with coronary artery disease: an in vitro study.
|
20559769 |
2010 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ESR1 genetic variants, haplotypes and the risk of coronary heart disease and ischemic stroke in the Finnish population: a prospective follow-up study.
|
20153472 |
2010 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Qualitative assessment of previous evidence and an updated meta-analysis confirms lack of association between the ESR1 rs2234693 (PvuII) variant and coronary heart disease in men and women.
|
19608186 |
2009 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor alpha polymorphism.
|
19008156 |
2009 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography.
|
19318036 |
2009 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There have been studies examining the association between coronary artery disease and the estrogen receptor alpha (ESR1) gene.
|
18360040 |
2008 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population.
|
18582450 |
2008 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The relationship of the ESR1 gene polymorphisms with the presence of coronary artery disease determined by coronary angiography.
|
18294052 |
2007 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effect of hormone replacement therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha IVS1-397 C/C genotype and established coronary artery disease.
|
16612068 |
2006 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor 1 gene polymorphisms and coronary artery disease in the Brazilian population.
|
16612467 |
2006 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In previous association studies, the -397T/C (rs2234693) and -351A/G (rs9340799) single nucleotide polymorphisms in the estrogen receptor alpha gene (ESR1) have been implicated in the risk of coronary atherosclerosis and myocardial infarction.
|
16203927 |
2005 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor alpha gene polymorphisms are associated with the angiographic extent of coronary artery disease.
|
16159931 |
2005 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The reported association has the potential to explain the risks associated with estrogen use in certain women and a recent report of association between an ESR1 haplotype comprised of c.454-397 T and c.454-351 A alleles with increased myocardial infarction and ischaemic heart disease, independent of the standard, established cardiovascular risk factors.
|
16014638 |
2005 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor alpha (ESR1) gene variation is associated with a range of important estrogen-dependent characteristics, including responses of lipid profile and atherosclerotic severity to hormone replacement therapy, coronary heart disease risk, and migraine.
|
16179580 |
2005 |
Coronary Arteriosclerosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Short-term transdermal estradiol enhances nitric oxide synthase III and estrogen receptor mRNA expression in arteries of women with coronary artery disease.
|
16207548 |
2005 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease.
|
14972425 |
2004 |
Coronary Arteriosclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the estrogen receptor alpha gene in men with coronary artery disease: association with disease status.
|
12691862 |
2003 |