Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The ERα-PvuII polymorphism could be considered as a possible protective factor against male infertility.
|
30738766 |
2019 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis.
|
31120775 |
2019 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The compounds with the strongest evidence of efficacy and the most used in clinical practice for the treatment of idiopathic male infertility are follicle-stimulating hormone (FSH) and estrogen receptor selective modulators (SERMs).
|
30407872 |
2019 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
This meta-analysis suggested that polymorphisms in the genes of ERs (ESR1 and ESR2) may have differential roles in the predisposition to male infertility according to the different ethnic backgrounds.
|
24647635 |
2014 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Here, we utilized a transgenic mouse strain that overexpresses human CYP19, which encodes aromatase (AROM+ mice), and mice with knockout of Esr1, encoding estrogen receptor α (ERαKO mice), to analyze interactions between viable Leydig cells (LCs) and testicular macrophages that may lead to male infertility.
|
24762434 |
2014 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
It is concluded that as oestrogen is concerned in male gamete maturation, ER-α gene polymorphisms might play a role in the pathophysiology of male infertility.
|
23822672 |
2014 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Our findings further support a possible role of ERα in male infertility.
|
23913373 |
2013 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Transactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function.
|
23213263 |
2012 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We investigated the association between the ER-α gene (ESR1) PvuII and XbaI and ER-β gene (ESR2) RsaI and Alul polymorphisms and the idiopathic male infertility in Iranian males.
|
20599614 |
2010 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype.
|
20833731 |
2010 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Molecular analysis of estrogen receptor alpha gene AGATA haplotype and SNP12 in European populations: potential protective effect for cryptorchidism and lack of association with male infertility.
|
17099213 |
2007 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Although the importance of estrogens in male reproduction is indisputable, little attention has been paid to the role of estrogen receptor (ER) gene mutations in male infertility.
|
16396937 |
2006 |
Male infertility
|
0.400 |
Biomarker
|
phenotype |
LHGDN |
Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology.
|
16213843 |
2005 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology.
|
16213843 |
2005 |
Male infertility
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Association of oestrogen receptor alpha polymorphisms and androgen receptor CAG trinucleotide repeats with male infertility: a study in 109 Greek infertile men.
|
12031042 |
2002 |