Prostate carcinoma
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
Our results support the conclusion that C/EBPβ down-regulated ERβ expression through increasing its promoter methylation, and then regulated proliferation and apoptosis in PCa.
|
29322786 |
2019 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of ZFHX3 and ERβ in human prostate cancer tissue samples correlated with better patient survival.
|
30979864 |
2019 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the present study, the role of ERβ in lipopolysaccharide (LPS)‑induced inflammation and association with NF‑κB activity were investigated in PC‑3 and DU145 prostate cancer cell lines.
|
30864712 |
2019 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, our data demonstrated that bakuchiol inactivated NF-κB signaling via AR and ERβ, which contributes to inhibition of PC-3 cell proliferation and migration, indicating that bakuchiol is one of the key component from P. corylifolia L for PCa treatment and has a potential as anti-prostate cancer drug candidates.
|
30236540 |
2018 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear.
|
30326857 |
2018 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The analysis of several immortalized cell lines derived from freshly explants of prostate cancer specimens showed that Nup153 protein was higher and present in multimeric complexes with eNOS and ERβ as compared to normal/hyperplastic prostate epithelial cells.
|
29963256 |
2018 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The expression of estrogen receptor (ER)-β appears to be lost during prostate cancer progression through hypermethylation mechanism.
|
29455003 |
2018 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, ARs; estrogen receptors (ERs; ERα and ERβ); and estrogen-related receptors (ERRs; ERRα, ERRβ, and ERRγ) have been reported to be involved in the development or regulation of PC.
|
29360794 |
2018 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, distinct ERβ dynamics in various cellular bio-settings such as prostate cancer (DU-145) or triple-negative breast cancer (MDA-MB-231) cells were directly observed for the first time viaFPNM staining.
|
29610818 |
2018 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Additionally, FTY720 abolished estrogen-stimulated expression of ERα and basal expression of ERβ within prostate cancer cells.
|
29654831 |
2018 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor beta (ERβ) splice variants are implicated in prostate cancer (PC) progression; however their underlying mechanisms remain elusive.
|
28968951 |
2017 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, transfection experiment of ERβ-siRNA further indicated that diosicn showed excellent activity against PCa in vitro and in vivo by increasing ERβ expression level.
|
28796245 |
2017 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Considering a combination marker panel of MCAM, ERα and ERβ increased the sensitivity to 75% and the specificity became 70% for the minimally invasive early detection test of PC.
|
28147335 |
2017 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
ERβ is commonly studied in MCF-7 (breast) and LNCaP (prostate) cancer cell lines, but we found no ERβ expression in either, using validated antibodies and independent mass spectrometry-based approaches.
|
27889472 |
2017 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although it is speculated that ERα is associated with harmful effects on PCa, the role of ERβ in PCa is still ill-defined.
|
28503095 |
2017 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Involvement of estrogen receptor β in androgen receptor-induced growth inhibition in prostate cancer PC-3 cells.
|
28928821 |
2017 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results support the conclusion that abnormal methylation of the ERβ promoter may increase genetic susceptibility to prostate cancer.
|
26547439 |
2016 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
It potently and selectively inhibited cell proliferation of prostate cancer (PC3/DU145) cells in comparison to normal (non-cancer) cells by promoting cell-cycle arrest and apoptosis, accompanied with inhibition of total DNMT activity, and re-expression of ER-β (mRNA/protein).
|
26599461 |
2016 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although, an increasing body of evidence has linked estrogen receptor beta (ERß) to prostate cancer, the function of estrogen receptor alpha (ERα) in prostate cancer is not very well studied.
|
26575018 |
2015 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This finding provides a mechanism for how ERβ expression is regulated in prostate cancer.
|
25818291 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10(-8); PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10(-10); ESR2).
|
26443449 |
2015 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Clinical significance of estrogen receptor β in breast and prostate cancer from biological aspects.
|
25611678 |
2015 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These findings provide a novel mechanism for how ERβ prevents NF-κB activation and raise the exciting possibility that loss of ERβ expression is linked to chronic inflammation in the prostate, which contributes to the development of high-grade prostate cancer.
|
26450901 |
2015 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
ERβ is epigenetically silenced in prostate cancer patients, therefore our results suggest that combination of ERβ agonists with ADT would benefit men stratified on the basis of high estrogen levels.
|
25816367 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |