|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.
|
23977064 |
2013 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients.
|
22179046 |
2011 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An Ets2-TAM expression signature consisting of 133 genes was identified within human breast cancer expression data which could retrospectively predict overall survival of patients with breast cancer in two independent data sets.
|
20145133 |
2010 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ets2 transcription factor, telomerase activity and breast cancer.
|
19566835 |
2010 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, hTERT gene expression is maintained by a mechanism involving Ets2 interactions with the c-Myc transcription factor and the hTERT gene promoter, a protein-DNA complex critical for hTERT gene expression and breast cancer cell proliferation.
|
18586674 |
2008 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In cohort II, CENP-F correlated with VEGFR2, phosphorylated Ets-2 and Ki67, and in multivariate analysis, was an independent predictor of worse breast cancer-specific survival (p=0.036) and overall survival (p=0.040).
|
17205517 |
2007 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As Ets2 binding sites are present on the uPA promoter, Ets2 may be one of the transcription factors regulating uPA expression in human breast cancer.
|
16380248 |
2006 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ets2 is expressed in prostate and breast cancer cells and is thought to have a role in promoting growth and survival in these cell types.
|
15314206 |
2004 |
|
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to investigate the role of PEA3 in tumor progression of ovarian and breast carcinoma metastatic to effusions, and to evaluate the expression of Ets-2 and Erg in ovarian carcinoma.
|
15387369 |
2004 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine whether the Ets2 transcription factor can also mediate CSF-1- and CSF-1R-stimulated signaling pathways in mammary epithelial cells, we expressed a dominant negative mutant, Ets2, in the CSF-1R- and Ets2-positive BT20 breast carcinoma cell line and examined its effects on CSF-1-induced cellular invasion and on colony formation in soft agar.
|
9500466 |
1998 |
|
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A genetic linkage map of human chromosome 21 has been constructed using 22 anonymous DNA markers and five complementary DNAs (cDNAs) encoding the amyloid beta protein precursor (APP), superoxide dismutase 1 (SOD1), the ets-2 proto-oncogene (ETS2), the estrogen inducible breast cancer locus (BCEI), and the leukocyte antigen, CD18 (CD18).
|
1347193 |
1992 |
|
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.
|
23977064 |
2013 |
|
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients.
|
22179046 |
2011 |
|
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
An Ets2-TAM expression signature consisting of 133 genes was identified within human breast cancer expression data which could retrospectively predict overall survival of patients with breast cancer in two independent data sets.
|
20145133 |
2010 |
|
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Ets2 transcription factor, telomerase activity and breast cancer.
|
19566835 |
2010 |
|
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Thus, hTERT gene expression is maintained by a mechanism involving Ets2 interactions with the c-Myc transcription factor and the hTERT gene promoter, a protein-DNA complex critical for hTERT gene expression and breast cancer cell proliferation.
|
18586674 |
2008 |
|
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
In cohort II, CENP-F correlated with VEGFR2, phosphorylated Ets-2 and Ki67, and in multivariate analysis, was an independent predictor of worse breast cancer-specific survival (p=0.036) and overall survival (p=0.040).
|
17205517 |
2007 |
|
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
As Ets2 binding sites are present on the uPA promoter, Ets2 may be one of the transcription factors regulating uPA expression in human breast cancer.
|
16380248 |
2006 |
|
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Ets2 is expressed in prostate and breast cancer cells and is thought to have a role in promoting growth and survival in these cell types.
|
15314206 |
2004 |
|
Malignant neoplasm of breast
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
A genetic linkage map of human chromosome 21 has been constructed using 22 anonymous DNA markers and five complementary DNAs (cDNAs) encoding the amyloid beta protein precursor (APP), superoxide dismutase 1 (SOD1), the ets-2 proto-oncogene (ETS2), the estrogen inducible breast cancer locus (BCEI), and the leukocyte antigen, CD18 (CD18).
|
1347193 |
1992 |
|
Mammary Neoplasms
|
0.360 |
AlteredExpression
|
group |
BEFREE |
Importantly, the Ets2-dependent gene expression signatures from both mouse models were able to distinguish human breast tumor stroma from normal stroma, and correlated with patient outcomes in two whole tumor breast cancer data sets.
|
23977064 |
2013 |
|
Mammary Neoplasms
|
0.360 |
Biomarker
|
group |
BEFREE |
In summary, we identified Ets2 as a central driver of a transcriptional program in TAMs that acts to promote lung metastasis of breast tumors.
|
20145133 |
2010 |
|
Mammary Neoplasms
|
0.360 |
AlteredExpression
|
group |
LHGDN |
Ets-2 and p160 proteins collaborate to regulate c-Myc in endocrine resistant breast cancer.
|
18059336 |
2008 |