|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ETV1 is a member of the ETS family of transcription factors, already known oncogenic drivers in Ewing sarcoma, prostate cancer and gastrointestinal stromal tumors, but not in gliomas.
|
31381204 |
2020 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we explored the potential agents targeting ETV1 in GISTs by uploading an ETV1 knockout gene signature of GIST cell lines to the pattern‑matching software 'Connectivity Map'.
|
31268158 |
2019 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Three significantly differential circRNAs (circ_0069765, circ_0084097, and circ_0079471) and their host genes (KIT, PLAT, and ETV1) were also verified in 68 pairs of GISTs and adjacent normal gastrointestinal tissues by qRT-PCR.
|
31552107 |
2019 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found high positive correlations between expression of H19 and known GIST related oncogene ETV1, and between H19 and miR-455-3p.
|
30557328 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, FOXF1 colocalizes with ETV1 at enhancers and functions as a pioneer factor that regulates the ETV1-dependent GIST lineage-specific transcriptome through modulation of the local chromatin context, including chromatin accessibility, enhancer maintenance, and ETV1 binding.
|
29162563 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
A new study now shows that the forkhead box (FOX) family transcription factor FOXF1 not only is an upstream regulator of ETV1 and hence ICC/GIST lineage-specific gene transcription, but also functions as lineage-specific pioneer factor with an active role in chromatin rearrangement to facilitate ETV1 binding and transcriptional activity.<i>Cancer Discov; 8(2); 146-9.
|
29431674 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recently, in situ hybridization (ISH) for E26 transformation-specific sequence variant 1 (ETV1) mRNA was introduced as a useful marker to diagnose GIST.
|
29245294 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we present a model in which the ETV1 promoter is used to specifically and inducibly drive Cre recombinase in ICC as a strategy to study GIST pathogenesis.
|
28539323 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The lineage transcription factor ETV1 is expressed similarly in GISTs regardless of malignant potential.
|
29371979 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These advances have characterized ETV1 as an essential interstitial cell of Cajal-GIST transcription factor in oncogenic KIT signaling pathways, and have characterized the biologically distinct subgroup of succinate dehydrogenase deficient GIST, which are particularly common in young adults.
|
28632504 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, ETV1 was positive in 15 of 26 (58 %) KIT-negative GISTs and even positive in 2 cases of GIST negative for KIT and DOG1, whereas only 6 (5 %) non-GIST mesenchymal GI tumors expressed ETV1.
|
26243012 |
2015 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
ETV1 is a lineage-specific oncogenic transcription factor required for the growth and survival of GIST.
|
25572173 |
2015 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ETV1 knockdown reduced KIT expression and GIST proliferation.
|
25865047 |
2015 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated CIC, ETV1, and the MAPK pathway in GIST.
|
24897389 |
2014 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the frequency of ETV1 positivity was higher when compared with KIT [50.0% (9/18) vs 38.9% (7/18)] particularly in high-risk GISTs.
|
24970355 |
2014 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry revealed that ETV1 expression in GIST had no prognostic significance.
|
23977394 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-17/20a/222 overexpression in GIST cell lines severely inhibited cell proliferation, affected cell cycle progression, induced apoptosis and strongly downregulated protein and--to a lesser extent--mRNA levels of their predicted target genes KIT and ETV1.
|
23969726 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Prominent ETV1 expression was seen in 50% of GISTs, but no correlation with clinical outcome was found.
|
22351694 |
2012 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We propose that GIST arises from ICCs with high levels of endogenous ETV1 expression that, when coupled with an activating KIT mutation, drives an oncogenic ETS transcriptional program.
|
20927104 |
2010 |