|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The observation that the different translocation partners of the EWS gene are specifically associated with several distinct types of primitive sarcomas suggests a model in which the translocation partner supplying the DNA-binding domain confers the target specificity of the transcriptional activation mediated by these chimeric proteins, whereas the partner supplying the N-terminal domain and promoter region determines their transactivation potential and expression level.
|
7493135 |
1995 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS-FLI1 or EWS-ERG fusions were detected in six of eight Ewing's sarcomas and one of seven undifferentiated sarcomas.
|
7530783 |
1995 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings are consistent with previous cytogenetic reports of a recurrent t(9;22)(q22-31;q11-12) in the myxoid variant of chondrosarcoma and reveal involvement of the EWS gene in a fourth type of human sarcoma.
|
7539287 |
1995 |
|
Malignant neoplasm of soft tissue
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Northern analysis and reverse transcriptase PCR reveal expression of EWS/FLI1 gene fusions in all biphenotypic sarcomas analyzed.
|
7882340 |
1995 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
We have determined the frequency of EWS fusion transcripts in a series of primary Ewing's sarcomas and peripheral primitive neuroectodermal tumors and cells lines.
|
8040301 |
1994 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
DSRCT thus represents the third primitive sarcoma in which the EWS gene is involved and the first instance of recurrent rearrangement of a tumor suppressor gene, WT1, in a specific tumor type.
|
8187063 |
1994 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
No EWS/FLI-1 fusion transcripts were detected in five cell lines derived from cases of pediatric sarcomas having a histological diagnosis other than Ewing's sarcoma/PNET.
|
8238248 |
1993 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS-FLI-1 is a chimeric protein produced in most Ewing's sarcomas.
|
8604338 |
1996 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
We assume that the RNA binding domain of EWS may have been replaced by the DNA binding domain of EIAF in the EWS-EIAF fusion protein as in other fusion proteins previously characterized in Ewing sarcoma and other types of sarcomas.
|
8834175 |
1996 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Homologies were found with the EWS oncogene, which is rearranged in Ewing sarcomas and other neoplasias.
|
8921363 |
1996 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The EWS/FLI1 fusion protein is created by the translocation between chromosomes 11 and 22 that appears in most Ewing's sarcomas.
|
9000139 |
1996 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Extraskeletal myxoid CS thus represents yet another sarcoma type containing a gene fusion involving EWS.
|
9060841 |
1997 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A t(11;22)(p13;p12) chromosomal translocation, juxtaposing the Wilms' tumor (WT1) and Ewing's sarcoma (EWS) genes, is the cytogenetic hallmark of desmoplastic small round cell tumor (DSRCT), a primitive multiphenotypic sarcoma arising in serosal tissues.
|
9071577 |
1997 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the present study, we determined the genomic breakpoint and characterized the chimeric transcript of the EWSR1-ETV4 fusion gene in two t(17;22) Ewing sarcomas.
|
9858836 |
1998 |
|
Malignant neoplasm of soft tissue
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The fusion genes found in sarcomas are dominated by the transcription factor type of genes with the TLS/FUS and EWS series of fusion genes as the largest group.
|
10448117 |
1999 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
RBP56 has not previously been shown to be involved in tumorigenesis but it encodes a putative RNA-binding protein similar to the EWS and FUS (TLS) proteins known to play a pathogenetic role in several sarcomas.
|
10602519 |
1999 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The EWS family of genes is involved in numerous chromosomal translocations that are characteristic of a variety of sarcomas.
|
11896622 |
2002 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
The most frequent fusion product associated with EFT, EWS-FLI1, is the founding member of a whole class of similarly structured chimeric proteins associated with a variety of human sarcomas and also specific leukemias.
|
12908547 |
2003 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS/ETS is a chimeric protein identified in most Ewing's sarcomas.
|
14678994 |
2003 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have shown that EWS/FLI-1 as well as related sarcoma fusion proteins are necessary and sufficient to induce transformation both in vitro and in vivo.
|
15183454 |
2004 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal.
|
15974803 |
2005 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Desmoplastic small round cell tumor (DSRCT) is a primitive sarcoma characterized by a recurrent chromosomal translocation, t(11;22)(p13;q12), which fuses the 5' exons of the EWS gene to the 3' exons of the WT1 gene.
|
16730884 |
2007 |
|
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The EWSR1 and FLI1 genes are involved in balanced translocation t(11;22)(q24;q12), which is present in more than 85% of Ewing sarcomas.
|
16837212 |
2006 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Although ESFTs are among the best studied sarcomas, the mechanisms involved in EWS-FLI-1-induced transformation require further elucidation and the primary cells from which ESFTs originate need to be identified.
|
17250957 |
2007 |
|
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have revealed that the pathognomonic translocations involving the EWS gene on chromosome 22 and an ETS-type gene, which is most commonly the Fli1 gene on chromosome 11, are implicated in more than 95% of Ewing's sarcomas, primitive neuroectodermal tumors and Askin's tumors.
|
17272319 |
2007 |