Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS/ETS is a chimeric protein identified in most Ewing's sarcomas.
|
14678994 |
2003 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS fusions with non-ETS transcription factor family members have been described in sarcomas that are clearly distinct from Ewing's sarcoma.
|
21872822 |
2011 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: angiomatoid fibrous histiocytoma, conventional clear cell sarcoma (of tendons and aponeuroses), clear cell sarcoma-like tumor of the gastrointestinal tract, hyalinizing clear cell carcinoma of the salivary gland, and primary pulmonary myxoid sarcoma.
|
22510762 |
2012 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWSR1 rearrangement was detected by FISH in 12/13 Ewing sarcomas/PNETs.
|
24293381 |
2014 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWSR1-PATZ1 fusion is a rare event in tumors: it was only reported in six round cell sarcomas and in three gliomas of three exclusively molecular studies.
|
29679497 |
2019 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWSR1-PATZ1 fusion positive spindle and round cell sarcomas show abundant intratumoral fibrosis and polyphenotypic differentiation, thus mimicking a range of tumors including desmoplastic small round cell tumor.
|
30379650 |
2019 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWSR1-NFATC2 sarcoma is a novel translocation-associated sarcoma.
|
30994538 |
2019 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWSR1-PATZ1 is a rare fusion partnering in sarcoma, with few cases reported in the literature.
|
31189996 |
2019 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS-FLI1 or EWS-ERG fusions were detected in six of eight Ewing's sarcomas and one of seven undifferentiated sarcomas.
|
7530783 |
1995 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
EWS-FLI-1 is a chimeric protein produced in most Ewing's sarcomas.
|
8604338 |
1996 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A t(11;22)(p13;p12) chromosomal translocation, juxtaposing the Wilms' tumor (WT1) and Ewing's sarcoma (EWS) genes, is the cytogenetic hallmark of desmoplastic small round cell tumor (DSRCT), a primitive multiphenotypic sarcoma arising in serosal tissues.
|
9071577 |
1997 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
A histologic comparison of the CIC-rearranged sarcomas with 20 EWSR1-rearranged Ewing sarcomas showed significantly higher degrees of lobulation, nuclear pleomorphism, the prominence of the nucleoli, spindle cell elements, and myxoid changes in the CIC-rearranged sarcomas.
|
26685084 |
2016 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
All 15 (100%) Ewing sarcomas/PNET and 4 clear cell sarcomas (4/4) harbored EWSR1 translocations.
|
25446247 |
2014 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Although ESFTs are among the best studied sarcomas, the mechanisms involved in EWS-FLI-1-induced transformation require further elucidation and the primary cells from which ESFTs originate need to be identified.
|
17250957 |
2007 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although we acknowledge that the present molecular classification of soft tissue tumours is much more complex than two decades ago, when EWSR1 gene rearrangements had been described as the hallmark of Ewing sarcoma, we make the strong argument that with very few exceptions, the prevalence of fusion transcripts in most sarcomas is such that they come to define these entities and can be used as highly specific molecular diagnostic markers in the right clinical and pathological context.
|
24378390 |
2014 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among the genes that can be rearranged, the EWSR1 gene has been identified as a partner in a wide variety of clinically and pathologically diverse sarcomas as well as some non-mesenchymal tumours.
|
24320889 |
2014 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Desmoplastic small round cell tumor (DSRCT) is a primitive sarcoma characterized by a recurrent chromosomal translocation, t(11;22)(p13;q12), which fuses the 5' exons of the EWS gene to the 3' exons of the WT1 gene.
|
16730884 |
2007 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
DSRCT thus represents the third primitive sarcoma in which the EWS gene is involved and the first instance of recurrent rearrangement of a tumor suppressor gene, WT1, in a specific tumor type.
|
8187063 |
1994 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Ewing sarcoma is a highly aggressive bone and soft tissue cancer that is caused by the EWS-FLI1 fusion protein.
|
27557498 |
2016 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Ewing sarcoma/peripheral neuroectodermal tumor (EWS/PNET), since its characterization immunophenotypically and cytogenetically, has emerged as one of most common sarcomas of childhood.
|
17487851 |
2007 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression profile comparisons with tumours of other sarcoma subtypes demonstrated that both cases clustered close to EWSR1-CREB1-positive tumours.
|
29533464 |
2018 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Extraskeletal myxoid CS thus represents yet another sarcoma type containing a gene fusion involving EWS.
|
9060841 |
1997 |
Malignant neoplasm of soft tissue
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we demonstrate that EWS-FLI1 contributed to secondary sarcoma development from the sarcoma iPSCs after osteogenic differentiation.
|
26997645 |
2016 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
From a molecular point of view, these neoplasias are grouped into 2 main types: (a) sarcomas showing relatively simple karyotypes and translocations, which originate gene fusions (eg, EWS-FLI1 in Ewing sarcoma) or point mutations (eg, c-kit in the gastrointestinal tumors) and (b) sarcomas showing unspecific gene alterations, very complex karyotypes, and no translocations.
|
20418671 |
2010 |
Malignant neoplasm of soft tissue
|
0.100 |
GeneticVariation
|
group |
BEFREE |
From the molecular point of view, these neoplasias are grouped into two main types: (a) sarcomas showing specific genetic alterations and relatively simple karyotypes, and translocations which originate gene fusions (e.g., EWS-FLI1 in Ewing tumour); or specific genetic mutations (e.g., c-kit in the gastrointestinal stromal tumour), and (b) sarcomas showing unspecific gene alterations and very complex karyotypes, and very numerous gains and losses.
|
17403624 |
2007 |