|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-FLI1 fusion transcripts were detected by reverse transcriptase polymerase chain reaction and direct sequencing, confirming the diagnosis of PNET/ES.
|
21063743 |
2011 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains.
|
8084618 |
1994 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of specific EWS-FLI1 or EWS-ERG transcripts in peripheral blood (PB) samples of patients being treated for ET was prospectively evaluated, and these data were correlated to their clinical status.
|
9836070 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This article reviews the clinicopathologic features of EWS/pPNET and desmoplastic small round cell tumor in the spectrum of tumors with EWS gene rearrangements.
|
22420726 |
2012 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing tumours (ET), including Ewing's sarcoma and peripheral primitive neuroectodermal tumour, are well characterised at the molecular level by a unique chromosomal rearrangement which fuses the EWS gene to one of two closely related ETS proto-oncogenes, FLI-1 or ERG.
|
7524604 |
1994 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor family consistently associated with chromosomal translocation and functional fusion of the EWS gene to any of several structurally related transcription factor genes.
|
10623711 |
2000 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS Fli-1, a fusion gene resulting from a t(11;22) translocation is found in 90% of both Ewing's sarcoma and primitive neuroectodermal tumor (PNET).
|
11118299 |
2000 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified EWS rearrangements in 8 of 10 cases (80%) of Ewing's Sarcoma/pPNET.
|
10078922 |
1999 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hypothesis of a primitive peripheral neuroectodermal tumor (PPNET) located in the kidney was promptly excluded: Histologically, the tumor was a clear cell renal cell carcinoma (RCC) and we did not observe an EWSR1 gene rearrangement.
|
23117075 |
2012 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to document EWS/ETS fusion gene expression in suspected pPNETs of adults as objective evidence for the existence of this tumor family in older patients.
|
9508202 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most Ewing tumors (ET), including Ewing sarcomas, peripheral primitive neuroectodermal tumors (PNET), and Askin's tumors, can be defined according to the specific chromosomal translocations t(11;22)(q24;q12) (EWS-FLI-1) or t(21;22)(q21;q12) (EWS-ERG).
|
9646032 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The detection of the EWS-FLI1 (20/25) and EWS-ERG (4/25) fusion transcripts resolved 24 of 25 cases of Ewing sarcoma/PNET.
|
20231617 |
2010 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively.
|
9496833 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) is a diagnostically challenging malignant round cell tumor with signature translocations involving the EWS gene.
|
16258512 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To the best of our knowledge, this is the first description of a fusion between EWSR1 and a chromatin-reorganizing gene in Ewing sarcoma/PNET and thus expands the EWSR1 functional partnership beyond transcription factor and zinc-finger gene families.
|
21113140 |
2011 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This undifferentiated sarcoma shows some features of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), including a diffuse reactivity for FLI1, but it shows only focal and weak reactivity for CD99 and is negative for a rearrangement of EWS, the molecular signature of ES/PNET.
|
17990934 |
2008 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, however, it was reported that by using highly sensitive nested RT-PCR, a high proportion of GCT displays chimeric EWS/FLI1 fusion transcripts, i.e., the molecular genetic feature previously known to be strongly associated with the Ewing family of tumors.
|
11519035 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma family tumors (ESFTs), which include peripheral primitive neuroectodermal tumors (PNETs), are characterized by chromosomal translocations that generate fusions between the EWS gene and ETS-family transcription factors, most commonly FLI1.
|
21979944 |
2012 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
One desmoplastic small round cell tumor was found to have a variant EWS-WT1 chimeric product that included exon 8 of EWS EWS-FLI-1 chimeric RNA was present in all Ewing's sarcoma/primitive neuroectodermal tumor and not identified in any other tumor types, including desmoplastic small round cell tumor.
|
7495283 |
1995 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rearrangements of the EWS gene with ETS transcription factor genes as a result of chromosomal translocation and high expression levels of CD99MIC2 characterize the Ewing family of tumors (EFT).
|
10565682 |
1999 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Ewing's sarcomas and related peripheral primitive neuroectodermal tumors, a t(11;22) translocation or a (21,22) rearrangement is associated with hybrid transcripts of the EWS gene with the FLI1 or ERG gene.
|
8022439 |
1994 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Virtually all cases of Ewing's Sarcoma and peripheral Primitive Neuroectodermal Tumor (PNET) are associated with aberrant transcription factors which fuse amino-terminal EWS with the DNA binding moiety of an ETS transcription factor (FLI-1 in 90% of cases).
|
11313995 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aims of this study were (1) to present the diverse clinicopathological and molecular profile of EFTs in our settings, (2) to identify a pragmatic approach for diagnosing EFTs, especially for application of ancillary techniques, namely RT-PCR for specific transcripts (EWS-FLI1, EWS-ERG) and FISH for EWSR1 gene rearrangement, in certain cases and (3) to show the utility of tissue microarray in establishing a new FISH test.
|
24293381 |
2014 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pathologic studies revealed an Ewing sarcoma/peripheral primitive neuroectodermal tumor (EWS/pPNET) with typical features including periodic acid Schiff positive diastase sensitive cytoplasmic substance; strong membranous pattern of immunoreactivity for CD99, and a reciprocal translocation of t(11;22)(q24;q12) that was demonstrated by fluorescent in situ hybridization (FISH).
|
16196395 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET) are a group of small round cell sarcomas that show varying degrees of neuroectodermal differentiation characterized by translocation involving the EWS gene.Uterine ES/pPNET is a rare entity.
|
25303625 |
2015 |