|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Primitive neuroectodermal tumor (PNET) is a prototypic malignant small round cell tumor of childhood that is characterized in most cases by t(11;22) resulting in an EWS-FLI1 gene fusion.
|
11178636 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ewing sarcoma-primitive neuroectodermal tumor (EWS/PNET) belongs to the group of pediatric small round blue cell tumors; although EWS/PNET is classically a tumor of the soft tissue or bone in children and young adults, individual cases have been described in patients of all ages.
|
11679946 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) is a diagnostically challenging malignant round cell tumor with signature translocations involving the EWS gene.
|
16258512 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET) of the kidney is a rare and aggressive tumor.
|
17126256 |
2006 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma/peripheral neuroectodermal tumor (EWS/PNET), since its characterization immunophenotypically and cytogenetically, has emerged as one of most common sarcomas of childhood.
|
17487851 |
2007 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET.
|
18622580 |
2008 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS Fli-1, a fusion gene resulting from a t(11;22) translocation is found in 90% of both Ewing's sarcoma and primitive neuroectodermal tumor (PNET).
|
11118299 |
2000 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
|
15930281 |
2005 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-FLI1 fusion transcripts were detected by reverse transcriptase polymerase chain reaction and direct sequencing, confirming the diagnosis of PNET/ES.
|
21063743 |
2011 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-erg and EWS-Fli-1, which are involved in greater than 95% of Ewing family of tumors, were shown to function as transcriptional activators.
|
9178886 |
1997 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS/ets-oncogene fusion transcripts can be detected in at least 98% of Ewing tumors [(ET) Ewing sarcoma and peripheral primitive neuroectodermal tumor] by reverse transcriptase-polymerase chain reaction (RT-PCR), thus confirming the histopathologic diagnosis.
|
9495359 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel EWS-ERG rearrangement generating two hybrid mRNAs in a peripheral primitive neuroectodermal tumour (pPNET) with a t(15;22) translocation.
|
10209495 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements.
|
29034595 |
2018 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All 30 clinical specimens had been confirmed to contain sufficient ES/PNET DNA by the demonstration of a rearrangement of the t(11;22)-associated EWS gene using an EWS cDNA probe on the same blots.
|
7738717 |
1995 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All peripheral PNET tested expressed MIC2 and were positive for EWS-FLI1 (11/11).
|
11304041 |
2001 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a result of the t(11;22)(q24;q12) chromosomal translocation characterizing the Ewing family of tumors (ET), the amino terminal portion of EWS, an RNA binding protein of unknown function, is fused to the DNA-binding domain of the ets transcription factor Fli1.
|
9704926 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chimeric EWS/FLI1 transcripts and fusion proteins in these tumors are identical to those described for pPNETs.
|
7882340 |
1995 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: A case report.
|
27766786 |
2016 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of EWSR1 translocations - particularly t(11;22)(q24;q12) - is of great value in the differential diagnosis of the Ewing family of tumors.
|
20513536 |
2010 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of SYT and EWS gene rearrangements by dual-color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor.
|
20660338 |
2010 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Differentiating desmoplastic small round cell tumor (DSRCT) from another similar small round cell tumor of childhood, the Ewing sarcoma/primitive neuroectodermal tumor (EWS/PNET), can be difficult because morphologic and immunohistochemical features overlap.
|
10989634 |
2000 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumors (PNETs) are associated with a chromosomal translocation resulting in a fusion of the amino-terminus of EWS with the DNA-binding domain of an ETS transcription factor (most commonly FLI1 or ERG).
|
12557222 |
2003 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing sarcoma and other peripheral primitive neuroectodermal tumors (pPNETs) display limited neural differentiation and are thought to have a neural crest origin Greater than 95% of these tumors share common t(11;22)(q24;q12) ort(21;22)(q22;q12) chromosomal translocations leading to ES/FLI1 or EWS/ERG gene fusions, respectively.
|
9496833 |
1998 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing tumours (ET), including Ewing's sarcoma and peripheral primitive neuroectodermal tumour, are well characterised at the molecular level by a unique chromosomal rearrangement which fuses the EWS gene to one of two closely related ETS proto-oncogenes, FLI-1 or ERG.
|
7524604 |
1994 |
|
Ewings sarcoma-primitive neuroectodermal tumor (PNET)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor family consistently associated with chromosomal translocation and functional fusion of the EWS gene to any of several structurally related transcription factor genes.
|
10623711 |
2000 |