|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of EWSR1 translocations - particularly t(11;22)(q24;q12) - is of great value in the differential diagnosis of the Ewing family of tumors.
|
20513536 |
2010 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.
|
20308673 |
2010 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
First, we analyzed the expression of CAV1 by immunostaining a tissue microarray containing 43 paraffin-embedded ESFT tumors with known EWS translocations.
|
21106507 |
2010 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to EWS/FLI1 gene fusion, copy number changes are known to be significant for the underlying neoplastic development of ESFT and for patient outcome.
|
19144156 |
2009 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of EFTs is confirmed by molecular diagnostic testing showing the presence of established rearrangements of the EWS gene.
|
19411158 |
2009 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The molecular hallmark of the Ewing's family of tumors is the presence of balanced chromosomal translocations, leading to the formation of chimerical transcription factors (that is, EWS/FLI1) that play a pivotal role in the pathogenesis of Ewing's tumors by deregulating gene expression.
|
18591936 |
2008 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a result, it was not until the discovery that these tumors share a common underlying molecular pathogenesis (chromosomal translocations involving the EWS gene and one of several members of the ETS family of transcription factors) that significant advances in the diagnosis and therapy of ESFT became possible.
|
18088234 |
2008 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) indicated a rearrangement of the EWS region on chromosome 22, which is highly specific for Ewing's sarcoma and PNET, which are referred to as the Ewing's sarcoma family of tumors (EFT).
|
17610475 |
2007 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report may provide an opportunity for further evaluation of the EWS-FLI1 type 1 fusion gene and detection of prognostic significance in periosteal ESFT.
|
17762498 |
2007 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR to detect EWS-ETS gene arrangements is widely used to confirm the diagnosis of Ewing's family of tumors.
|
17272319 |
2007 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the other case, a variety of molecular studies did not reveal a translocation involving the EWS gene but this tumour, on the balance of probability, is still considered to represent a neoplasm in the EFTs.
|
17557870 |
2007 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumors of the Ewing family are characterized by chromosomal translocations that yield chimeric transcription factors, such as EWS/FLI1, which regulate the expression of specific genes that contribute to the malignant phenotype.
|
17438102 |
2007 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Together, our study represents a first approach to the separation of essential molecular consequences from noise generated by the EWS-FLI1 gene rearrangement in ESFT.
|
17163154 |
2006 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
High CD99 expression levels and rearrangements of the EWS gene with ETS transcription factor genes characterize the Ewing's sarcoma family of tumors (ESFT).
|
16314831 |
2006 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
All cases of ESFT were confirmed to have a rearranged EWS gene.
|
16721801 |
2006 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endogenous RHA was identified in a protein complex with EWS-FLI1 in ESFT cell lines.
|
16740692 |
2006 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ewing sarcoma family of tumors research has benefited from new target discovery and enhanced biologic understanding of the EWS-FLI1 fusion protein.
|
15659957 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is not a single condition, but a group of morphologically and clinically closely related disorders with similar molecular biology -- expression of tumor-specific chimeric oncoproteins through balanced chromosomal translocations involving the EWS gene -- often referred to as the Ewing family of tumors.
|
15877528 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The translocation t(11;22)(q24;q12) is the most common and leads to the formation of the EWS-FLI1 fusion protein, which contributes to ESFT pathogenesis by modulating the expression of target genes.
|
16096383 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pathologic studies revealed an Ewing sarcoma/peripheral primitive neuroectodermal tumor (EWS/pPNET) with typical features including periodic acid Schiff positive diastase sensitive cytoplasmic substance; strong membranous pattern of immunoreactivity for CD99, and a reciprocal translocation of t(11;22)(q24;q12) that was demonstrated by fluorescent in situ hybridization (FISH).
|
16196395 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first study in India with quantitative information about the types of EWS-FLI 1 translocations present in Ewing's family of tumours in south Indian patients.
|
16052075 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.
|
15930281 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular detection of EWS-Ets fusion transcripts and their clinicopathologic significance in Ewing's sarcoma/peripheral primitive neuroectodermal tumor.
|
16157025 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experiments using ESFT cell lines or animal xenograft models have proven that EWS-FLI1 is required for tumor survival.
|
16556028 |
2005 |
|
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively monitored tumor contamination in stem cell harvests from patients with Ewing family of tumors (EFT) all harboring the specific translocation EWS-FLI-1 that characterize these tumors.
|
15049010 |
2004 |