|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, molecular detection of EWSR1-WT1 fusion gene conclusively confirmed the diagnosis of DSRCT in this uncommon location.
|
31103034 |
2019 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Desmoplastic Small Round Cell Tumor (DSRCT) is a rare sarcoma tumor of adolescence and young adulthood, which harbors a recurrent chromosomal translocation between the Ewing's sarcoma gene (EWSR1) and the Wilms' tumor suppressor gene (WT1).
|
29626752 |
2018 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In these challenging cases, detection of an EWSR1-WT1 rearrangement and selective WT1 carboxy-terminus immunoreactivity (characteristic of DSRCT) or dual immunoreactivity for the WT1 amino-terminus and carboxy-terminus (characteristic of WT) remain the most discriminating diagnostic tools.
|
24832162 |
2014 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One SNP in EWSR1 (rs2857461) showed a low level of statistical association with the diagnosis of Ewing sarcoma compared to Wilms tumor.
|
21793187 |
2012 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The novel fusion of exon 8 of EWS and the defective exon 10 of WT1 (-KTS) was detected.
|
17021139 |
2006 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Desmoplastic small cell tumor (DSCT) is a distinct type of small blue cell tumors and is characterized by the unique karyotypic aberration involving the fusion of the Ewing's sarcoma (EWS) gene and Wilms' tumor (WT1) gene.
|
15166674 |
2004 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Desmoplastic small round cell tumor (DSRCT) is defined by a chimeric transcription factor, resulting from fusion of the N-terminal domain of the Ewing's sarcoma gene EWS to the three C-terminal zinc fingers of the Wilms' tumor suppressor WT1.
|
12923058 |
2003 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWS-WT1 is a chimeric transcription factor resulting from fusion of the N-terminal domain of the Ewing sarcoma gene EWS to the three C-terminal zinc fingers of the Wilms tumor suppressor WT1.
|
11960373 |
2002 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This chromosomal translocation generates a chimeric transcript that is formed by fusion of the 5' region of the Ewing's sarcoma gene, EWS, with the 3' DNA-binding segment of WT1, the Wilms' tumor suppressor gene.
|
10999739 |
2000 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For cases in which the morphologic and immunohistochemical features are consistent with a diagnosis of DSRCT, WT1 antibody staining predicts the EWS-WT1 translocation with high sensitivity and specificity and is, therefore, useful for differentiating DSRCT from EWS/PNET when genetic information is unavailable.
|
10989634 |
2000 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, a number of oncogenes, including mutant p53 and c-myb, and the fusion protein EWS-WT1 significantly stimulate promoter activity.
|
11001824 |
2000 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A t(11;22)(p13;p12) chromosomal translocation, juxtaposing the Wilms' tumor (WT1) and Ewing's sarcoma (EWS) genes, is the cytogenetic hallmark of desmoplastic small round cell tumor (DSRCT), a primitive multiphenotypic sarcoma arising in serosal tissues.
|
9071577 |
1997 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The WT-1 and EWS genes encode DNA and RNA binding proteins involved in Wilms' tumor and Ewing sarcoma pathogenesis, respectively.
|
8522311 |
1995 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Southern blot analysis revealed recurrent rearrangement of both EWS, located at 22q12, and rearranged in other tumor-specific translocations in Ewing's sarcoma and clear cell sarcoma, and of WT1, the gene at 11p13 involved in a subset of Wilms' tumor.
|
8187063 |
1994 |