|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWSR1 encodes an RNA-binding protein involved in multiple soft tissue tumors, including Ewing's sarcoma/peripheral neuroectodermal tumor, desmoplastic small round cell tumor, soft tissue clear cell sarcoma (malignant melanoma of soft parts), extraskeletal myxoid chondrosarcoma, and myxoid liposarcomas.
|
31774608 |
2020 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWSR1 rearrangements were first identified in Ewing sarcoma, but the spectrum of EWSR1-rearranged neoplasms now includes many soft tissue tumour subtypes including desmoplastic small round cell tumour (DSRCT), myxoid liposarcoma (MLPS), extraskeletal myxoid chondrosarcoma (EMC), angiomatoid fibrous histiocytoma (AFH), clear cell sarcoma (CCS) and myoepithelial neoplasms.
|
28141799 |
2017 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we studied a subgroup of sarcomas and leukaemias characterized by the FET (FUS, EWSR1, TAF15) family of fusion oncogenes, including FUS-DDIT3 in myxoid liposarcoma (MLS).
|
26865464 |
2016 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.
|
22570737 |
2012 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
EWSR1 FISH was sensitive among high-grade round cell sarcomas (positive in 100% of desmoplastic small round cell tumors and 96% of Ewing sarcoma/primitive neuroectodermal tumors) but not specific because clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and a subset of round cell liposarcomas also harbor rearrangements of EWSR1.
|
21128778 |
2010 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To that end, dual-color, break-apart fluorescence in situ hybridization (FISH) probes spanning the genomic regions of EWSR1 (22q12), DDIT3 (12q13), and FUS (16p11) (Vysis, Downer's Grove, IL) were evaluated in formalin-fixed, paraffin-embedded tissues from myxoid neoplasms, including intramuscular myxoma (n=10), myxoid liposarcoma (n=18), low-grade fibromyxoid sarcoma (n=10), extraskeletal myxoid chondrosarcoma (n=13), and myxofibrosarcoma (n=8).
|
18162764 |
2008 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to study the usefulness of trabectedin in the treatment of patients with myxoid liposarcomas, a subtype of liposarcoma that is associated with specific chromosomal translocations t(12;16)(q13;p11) or t(12;22)(q13;q12) that result in the formation of DDIT3-FUS or DDIT3-EWSR1 fusion proteins.
|
17586092 |
2007 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion.
|
17647282 |
2007 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
We describe here a case of myxoid liposarcoma containing a novel EWS-CHOP chimeric transcript and identified the breakpoint occurring in intron 13 of EWS.
|
16884691 |
2006 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Generation of the novel monoclonal antibody against TLS/EWS-CHOP chimeric oncoproteins that is applicable to one of the most sensitive assays for myxoid and round cell liposarcomas.
|
16538055 |
2006 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid/round cell liposarcomas (MLS/RCLS) are characterized by chromosome translocations that result in formation of FUS-CHOP or EWSR1-CHOP fusion oncogenes.
|
15492825 |
2004 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma.
|
12169678 |
2002 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features.
|
9306965 |
1997 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sequenced the breakpoint regions in one acute myeloid leukemia (AML) with t(16;21)(p11;q22) resulting in the formation of a FUS/ERG hybrid gene and in four myxoid liposarcomas (MLS), three of which had the translocation t(12;16) (q13;p11) and a FUS/CHOP fusion gene and one with t(12;22;20)(q13;q12;q11) and an EWS/CHOP hybrid gene.
|
9315104 |
1997 |
|
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of the EWS and CHOP genes in myxoid liposarcoma.
|
8637704 |
1996 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS in 22q12 has a very high homology with FUS (also called TLS) in 16p11; the latter gene is rearranged in the t(12;16)(q13;p11) that characterizes myxoid liposarcoma.
|
7533529 |
1994 |