Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypermethylation-mediated inactivation of miR-124 predicts poor prognosis and promotes tumor growth at least partially through targeting EZH2/H3K27me3 in ESCC.
|
31197517 |
2019 |
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results indicate that linc-UBC1 is a novel oncogene in tumorigenesis and could promote the metastasis via EZH2 and E-cadherin, which may offer a possible therapeutic target in ESCC.
|
29552776 |
2019 |
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results of mechanism experiments suggested that DUXAP10 motivated ESCC progression through recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p21.
|
30215547 |
2018 |
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, PTEN, TP53, MDM2, E2F1, PRMT5, MCM2, RB1, CDKN1A, SHAD7 and EZH2 may be targeted by the miR-106b-25 cluster, and act together to regulate the development of ESCC.
|
29250158 |
2018 |
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression level of EZH2 mRNA was negatively correlated with the expression of miR-30d in the ESCC tissues.
|
28184915 |
2017 |
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggested the expression of EZH2 and H3K27me3 could serve as biomarkers in the prediction of ESCC patients' survival and ESCC metastasis.
|
26631178 |
2016 |
Squamous cell carcinoma of esophagus
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The inverse correlation of MEIS1 with metastasis, tumor staging, and the role of EZH2 in methylation, together with its correlation with stemness factor SOX2 expression, led us to predict cancer stemness properties for MEIS1 in ESCC.
|
26314854 |
2016 |
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clinically, when compared to normal adjacent tissues, esophageal tumor samples show upregulation of SOX4, EZH2, and HDAC3, and EZH2 expression is significantly increased in metastatic ESCC tissues.
|
25644061 |
2015 |
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
This noncoding RNA contributes to the development of ESCC by interacting with EZH2 to promote methylation of POU3F3, which encodes a transcription factor.
|
24631494 |
2014 |
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We undertook a case-control study to analyze three EZH2 polymorphisms (148505302C>T, 2110+6A>C and 626-394T>C) in an Han Chinese population, by extraction of genomic DNA from the peripheral blood of 476 patients with ESCC and 492 control participants, and performed EZH2 genotyping using DNA sequencing.
|
25036033 |
2014 |
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Through clinical investigation, we found that miR-98 and miR-214 expression was significantly lower in ESCC tissues than in matched normal tissues, and the expression level of miR-98 and miR-214 was inversely correlated to EZH2 protein expression and the clinical features such as pathological grade, tumor stage and lymph node metastasis in ESCC.
|
22867052 |
2012 |
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant EZH2 and BMI1 protein expression was observed in 19 (14.0%) and 23 (16.9%), respectively, of the 136 ESCCs.
|
21165554 |
2011 |
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of EZH2 expressions might be useful for predicting tumor response to CRT and prognosis for patients with ESCC.
|
19904743 |
2010 |