|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although both c-Myc and EZH2 have been implicated in regulating cisplatin resistance in ovarian cancer, the interplay between these two regulators is poorly understood.
|
30166592 |
2019 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
LINC00702 is upregulated in OC.It accelerates the progression of OC via interacting with EZH2 to inhibit the transcription of KLF2.
|
31389610 |
2019 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
LncRNA CACS15 accelerates the malignant progression of ovarian cancer through stimulating EZH2-induced inhibition of APC.
|
31737207 |
2019 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histone Methyltransferase EZH2: A Therapeutic Target for Ovarian Cancer.
|
29726819 |
2018 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.
|
29575713 |
2018 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity.
|
29434212 |
2018 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although EZH2 enzymatic inhibitors have shown antitumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because EZH2 can promote cancer independently of its histone methyltransferase activity.
|
29669287 |
2018 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enhancer of zeste homolog 2 (EZH2), which is overexpressed in a wide range of tumors, contributes to ovarian cancer malignancy in several different ways.
|
29630768 |
2018 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that the inhibition of EZH2 increased the expression of p16, and suppressed the proliferation and migration capabilities of ovarian cancer <i>in vitro</i>.
|
29435063 |
2018 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, ABT263 synergizes with an EZH2 inhibitor in vivo in ARID1A-inactivated ovarian tumor mouse models.
|
30297712 |
2018 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, we describe a peptide nucleic acids (PNA)-based approach to block the ability of HOTAIR to interact with EZH2 and subsequently inhibit HOTAIR-EZH2 activity and resensitize resistant ovarian tumors to platinum.
|
28420874 |
2017 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the mechanism underlying EZH2 promotion of ovarian cancer metastasis remains elusive.
|
28620234 |
2017 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo.
|
28706445 |
2017 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TGF-β-induced EMT in SKOV3 OC cells was associated with decreased levels of EZH2 and H3K27me3 (P<0.05).
|
27563817 |
2016 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interfering EZH2 Expression Reverses the Cisplatin Resistance in Human Ovarian Cancer by Inhibiting Autophagy.
|
27610467 |
2016 |
|
ovarian neoplasm
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer.
|
25077680 |
2015 |
|
ovarian neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Importantly, EZH2 inhibition caused regression of ARID1A-mutated ovarian tumors in vivo.
|
25686104 |
2015 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer.
|
24755199 |
2014 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conjecture that a simultaneous EZH2 inhibition and anti-estrogen therapy can constitute an effective combined therapeutic strategy against ovarian cancer.
|
25545504 |
2014 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of EZH2 inhibits growth of ovarian cancer as well as other human carcinomas.
|
24771265 |
2014 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53.
|
23603558 |
2013 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2.
|
21216927 |
2011 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
EZH2 is a potential therapeutic target for treatment of ovarian cancer.
|
21205084 |
2011 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of EZH2 by RNA interference (RNAi) resensitized drug-resistant ovarian cancer A2780/DDP cells to cisplatin and decreased the level of H3K27 trimethylation (H3K27me3).
|
20686362 |
2010 |