|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of factor V Leiden and prothrombin variant G20210A were determined in 41 patients age <50 years who had "normal" or "near normal" coronary arteries (no stenosis >50%) at angiography three to four weeks after MI (the study group) and compared with those in 114 patients who had at least one angiographic stenosis >50% after MI (the control group).
|
10987590 |
2000 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the 20210 G-->A mutation in the prothrombin gene is a genetic risk factor for MI.
|
10027711 |
1999 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate that neither the prothrombin gene 20210G-->A transition nor the factor V Leiden mutation are risk factors for myocardial infarction.
|
10195931 |
1999 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
CTD_human |
Our findings suggest that the 20210 G-->A mutation in the prothrombin gene is a genetic risk factor for MI.
|
10027711 |
1999 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a large cohort of US men, the G20210A prothrombin gene variant was not associated with increased risk of myocardial infarction or stroke.
|
10051291 |
1999 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association between the risk of myocardial infarction at a young age and genetic factors thought to be associated with an increased tendency to thrombosis (the polymorphisms 4G/5G of the PAI-1 gene, PIA1/PIA2 of the platelet glycoprotein IIIa, C3550T of the platelet glycoprotein Ib gene, G10976A of the factor VII gene, C677T of the methylenetetrahydrofolate reductase gene, G1691A of the factor V gene, and G20210A of the prothrombin gene), we performed a case-control study evaluating 200 survivors (185 men, 15 women) of myocardial infarction who had experienced the event before the age of 45 years and 200 healthy subjects with a negative exercise test, individually matched for sex, age, and geographic origin with the cases.
|
10381497 |
1999 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The prothrombin 20210A allele and its association with myocardial infarction.
|
10404757 |
1999 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is evident that neither the Factor V Leiden mutation nor the 20210 A prothrombin mutation is a major risk factor for myocardial infarction or stroke, unless accompanied by other classical risk factors, including diabetes mellitus, hypertension and smoking.
|
10468143 |
1999 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
CTD_human |
When a coagulation defect was present (ie, the 20210 AG prothrombin genotype or the factor V Leiden mutation), the risk of myocardial infarction for carriers versus noncarriers was 1.4 (95% CI, 0.9 to 2.2).
|
9531249 |
1998 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that being heterozygote for the allele variant 20210A of the prothrombin gene could be a genetic risk factor for developing myocardial infarction.
|
9539856 |
1998 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The very low prevalence of the A allele indicates that the prothrombin variant is not a major cause of venous thrombosis or myocardial infarction in blacks.
|
9851733 |
1998 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The mutation was not more frequent among patients with a history of myocardial infarction (2.2%, odds ratio 0.7; 95% confidence interval 0.27 to 2.05), and there was no evidence of an interaction between the prothrombin mutation and conventional cardiovascular disease risk factors.
|
9869153 |
1998 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
When a coagulation defect was present (ie, the 20210 AG prothrombin genotype or the factor V Leiden mutation), the risk of myocardial infarction for carriers versus noncarriers was 1.4 (95% CI, 0.9 to 2.2).
|
9531249 |
1998 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
CTD_human |
A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women.
|
9292507 |
1997 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women.
|
9292507 |
1997 |