|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reliability of Lupus Anticoagulant and Anti-phosphatidylserine/prothrombin Autoantibodies in Antiphospholipid Syndrome: A Multicenter Study.
|
30891041 |
2019 |
|
Antiphospholipid Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies are often detected in patients with antiphospholipid syndrome (APS), but how aPS/PT engage prothrombin at the molecular level remains unknown.
|
31175129 |
2019 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antiphosphatidylserine/prothrombin complex antibodies as a determinant of prothrombotic plasma fibrin clot properties in patients with antiphospholipid syndrome.
|
31220407 |
2019 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prothrombin fragment F1 + 2 (F1 + 2) and thrombin-antithrombin (TAT) have been assessed in antiphospholipid syndrome (APS) but without evaluating a direct relationship with antiphospholipid (aPL) antibody titers.
|
31234212 |
2019 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the use of DOACs in unusual VTE, including cerebral venous thrombosis (CVT) and splanchnic venous thrombosis (SVT), and in patients with biological thrombophilia including minor thrombophilia (Factor V Leiden and prothrombin G20210A), major innate thrombophilia (protein C and S deficiency, and antithrombin) and major acquired thrombophilia (antiphospholipid syndrome [APS]), remains controversial due to the paucity of available data.
|
29402471 |
2018 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
First-Line, Non-Criterial Antiphospholipid Antibody Testing for the Diagnosis of Antiphospholipid Syndrome in Clinical Practice: A Combination of Anti-β<sub>2</sub> -Glycoprotein I Domain I and Anti-Phosphatidylserine/Prothrombin Complex Antibodies Tests.
|
28686816 |
2018 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.
|
29895622 |
2018 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia.
|
30008452 |
2018 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the prevalence of prothrombotic polymorphisms (G1691A of factor V gene [FV Leiden] and G20210A of prothrombin [FII] gene), deficiencies of natural anticoagulants (protein C, protein S and antithrombin III) and antiphospholipid syndrome (APS) in patients with early ST-segment elevation MI (STEMI).
|
28647870 |
2017 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diagnostic value of antibodies to phosphatidylserine/prothrombin complex for antiphospholipid syndrome in Chinese patients.
|
28050648 |
2017 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prothrombin-associated antibodies were helpful in confirming the diagnosis of antiphospholipid syndrome.
|
28116654 |
2017 |
|
Antiphospholipid Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical performance of antibodies to prothrombin and thrombin in Chinese patients with antiphospholipid syndrome: potential interest in discriminating patients with thrombotic events and non-thrombotic events.
|
27807637 |
2017 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Well‑known factors that result in predisposition to congenital disorders associated with thrombophilia include antithrombin deficiency, protein C and S deficiency, Factor V Leiden mutation, abnormal prothrombin and antiphospholipid syndrome.
|
28259966 |
2017 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several recommendations should be considered in Chinese BCS patients: (i) screening for hyperhomocysteinaemia and MTHFR mutation should be regularly performed; (ii) screening for MPNs, PNH, and anti-phospholipid syndrome should be selectively performed; (iii) inherited anti-thrombin, protein C, and protein S deficiencies should be actively explored; (iv) screening for FVL and prothrombin G20210A mutations may be unnecessary; and (v) the clinical significance of pregnancy and puerperium, poverty with bacterial infections and unsanitary environments, and family history as possible risk factors should never be neglected.
|
27734511 |
2016 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current case-control study was aimed to determine the prevalence and the clinical significance of inherited thrombophilia - factor V Leiden and G20210A prothrombin polymorphisms - in patients with antiphospholipid syndrome (APS).
|
24093662 |
2014 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Risk factors for initial thrombosis are antiphospholipid syndrome and heterozygous mutation for prothrombin G20210A.
|
22964766 |
2012 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated.
|
19005247 |
2009 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common abnormalities were: Factor V Leiden (N=376), antiphospholipid syndrome (N=289), and prothrombin G20210A (N=263).
|
19101711 |
2009 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the mutated allele 20210A of the prothrombin gene was higher in patients when compared with controls (5 versus 0.7%; P = 0.01), suggesting that prothrombin variant could increase the risk of thrombosis in patients with antiphospholipid syndrome.
|
11085290 |
2000 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism of the prothrombin gene in Mexican mestizo patients with antiphospholipid syndrome does not seem to be related to the thrombophilia observed in these patients.
|
10726001 |
1999 |
|
Antiphospholipid Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is possible that patients with the prothrombin 20210A mutation and ischemic cerebral vascular disease would benefit from long-term anticoagulation therapy in a similar way to patients with the antiphospholipid syndrome.
|
9890720 |
1998 |