F2R, coagulation factor II thrombin receptor, 2149

N. diseases: 347; N. variants: 10
Disease: Lupus Erythematosus, Systemic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.020 Biomarker disease BEFREE In conclusion, PAR-1 and PAR-2 are involved in FXa-mediated intracellular Ca<sup>2+</sup> release in HUVEC and FXa reactive IgG from patients with APS and/or SLE potentiate this effect. 28883515 2017
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.020 Biomarker disease BEFREE Taken together, the uniqueness of the translocation, the rarity of severe prepubertal SLE in males, and the presence of SLE in some patients with Klinefelter's syndrome (who have a triplication of the 2 PAR regions) point to a possible relationship between the partial triplication of the PAR1 region and the development of SLE. 16575839 2006