|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previous suggested that PAR-2 and CRTh2 expression on specific peripheral blood cell subtypes may be biomarkers of asthma severity.
|
31168305 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surprisingly, Par2 deficiency had no negative impact on the change of lung function, inflammation and cytokine production in the mouse model of Alt-induced asthma.
|
31430011 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protease-activated receptor 2 (PAR-2), an airway epithelial pattern recognition receptor (PRR), participates in the genesis of house dust mite-induced (HDM-induced) asthma.
|
29911993 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model.
|
28940559 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly to other asthma-associated allergens, Alternaria secretes a serine-like trypsin protease(s) that is thought to act through the G protein-coupled receptor protease-activated receptor-2 (PAR<sub>2</sub>) to induce asthma symptoms.
|
30335499 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have identified three different serine proteinases from the German cockroach that may, via PAR2 activation, play different roles for allergen sensitization in vivo and may represent attractive therapeutic targets for asthma.
|
28317204 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, increased expression of PAR-2 in monocytes of AR and asthma implicates that PAR-2 likely play a role in allergy.
|
27423452 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PAR-2 expression is increased on CD14++CD16+ monocytes in the peripheral blood of subjects with severe asthma and may be a biomarker of asthma severity.
|
26658828 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.
|
24551046 |
2014 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAR-2 expression is known to be upregulated in respiratory epithelium subsequent to inflammation in asthma and chronic obstructive pulmonary disease (COPD).
|
18077203 |
2008 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Asthma is characterized by bronchial inflammation and hyperresponsiveness that involves mast cell tryptase and potentially its specific receptor protease activated receptor 2 (PAR-2).
|
16195539 |
2006 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
PAR-2 activation, PGE2, and COX-2 in human asthmatic and nonasthmatic airway smooth muscle cells.
|
12754192 |
2003 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We determined the influence of chronic smoking and asthma on the expression of PAR-1 and PAR-2 receptors on alveolar macrophages (AMs).
|
12589358 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, compared with wild-type animals, airway hyperreactivity to inhaled methacholine (40 micro g/ml) was diminished 38% in mice lacking PAR2 and increased by 52% in mice overexpressing PAR2.
|
12391252 |
2002 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BHR, asthma and increased IgE were found to be linked to X and Y long arm pseudoautosomal region (PAR2) markers.
|
10641562 |
1999 |