F2RL1, F2R like trypsin receptor 1, 2150

N. diseases: 256; N. variants: 4
Disease: Atherosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 AlteredExpression disease BEFREE RESULTS Expression of PAR2 was higher in patients with atherosclerosis compared with normal controls. 31756174 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE Bone marrow transplantation showed that PAR2 on nonhematopoietic cells contributed to atherosclerosis. 29599135 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice. 29700120 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE To directly examine the role of PAR-2 in atherosclerosis, we generated apolipoprotein E/PAR-2 double-deficient mice. 28959204 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 AlteredExpression disease BEFREE These findings suggest that FXa/FIIa inhibition limits aortic aneurysm and atherosclerosis severity due to down-regulation of vascular PAR-2-mediated Smad2/3 signalling and MMP2 expression. 28220880 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE MT-SP1/matriptase is expressed in monocytes, thus, interaction of monocytic MT-SP1/matriptase with endothelial PAR-2 may contribute to atherosclerosis. 17255532 2007