F2RL1, F2R like trypsin receptor 1, 2150

N. diseases: 256; N. variants: 4
Disease: Lung diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.220 Biomarker group BEFREE Inhibition of the CatS target, protease-activated receptor 2 (PAR2), in βENaC-Tg mice resulted in a reduction in airway inflammation and mucin expression, indicating a role for this receptor in CatS-induced lung pathology.Our data indicate an important role for CatS in the pathogenesis of CF-like lung disease mediated in part by PAR2 and highlight CatS as a therapeutic target. 30655278 2019
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.220 Biomarker group BEFREE Mast cells and the mast cell mediator tryptase may have crucial roles in inducing lung fibroblast migration via PAR-2 activation, which may contribute to remodeling processes in chronic lung diseases. 30219079 2018
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.220 Biomarker group RGD Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. 19766246 2011