F2RL1, F2R like trypsin receptor 1, 2150

N. diseases: 256; N. variants: 4
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 Biomarker disease BEFREE We showed that PAR2 and its activating proteinase were coexpressed in different colon cancer cell lines, including HT29. 23991105 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 Biomarker disease BEFREE Our previous study has demonstrated that TF/FVIIa and PAR2 are closely related to the proliferation and migration of colon cancer cell line SW620. 23170789 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 Biomarker disease BEFREE Involvement of PKCα activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620. 23233043 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 AlteredExpression disease BEFREE Previously, we reported that PAR2 could be expressed in human colon cancer cell line (SW620) and its activation by some stimulants was able to facilitate cell proliferation and migration. 21152870 2011
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 Biomarker disease BEFREE Here, we analyzed the signaling pathways downstream of PAR2 activation that lead to colon cancer cell proliferation in HT-29 cells. 15010475 2004
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 Biomarker disease BEFREE In the present study, we investigated the effects of PAR-2 stimulation on the cell signaling and proliferation of DLD-1, a human colon carcinoma cell line, in comparison with the PAR-1 stimulation. 14511767 2003
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.070 AlteredExpression disease BEFREE Altogether, these data show that colon cancer cell lines produce and secrete trypsin at concentrations compatible with activation of PAR-2. 11883712 2002